Agent Name

Dichloroethyl ether

Alternative Name

2,2'-Dichlorodiethyl ether

CAS Number

111-44-4

Formula

C4-H8-Cl2-O

Major Category

Other Classes

Synonyms

2,2'-Dichlorodiethyl ether; Bis(2-chloroethyl)ether; 2,2`-Dichloroethyl ether; 2,2'-Dichlorodiethyl ether; [NIOSH] UN1916

Category

Halogenated Ethers

Description

Colorless liquid with a chlorinated solvent-like odor; [NIOSH]

Sources/Uses

Used as a solvent, dewaxing agent, wetting agent, soil fumigant, and chemical intermediate; [ACGIH] Used to control earworms on corn silks; No longer used as a soil fumigant; [HSDB]

Comments

Damage to the lungs, liver, kidneys, and brain occur in studies of guinea pigs and rats at 500 ppm for 5 to 8 hours. Volunteers found exposures above 550 ppm intolerable because of nauseating odor and irritation of the eyes, nose, and respiratory tract. [ACGIH] The vapor can cause lacrimation.[HSDB] A severe eye irritant; [CHEMINFO]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm

STEL (ACGIH)

10 ppm

PEL (OSHA)

Ceiling(OSHA) = 15 ppm

MAK

10 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statements by Patty [1963] that 250 ppm caused death in rats from a 4hour exposure [Carpenter et al. 1949] and that 500 to 1000 ppm might cause death in guinea pigs from an exposure of only 30 to 60 minutes duration [Schrenk et al. 1933]. . . . Human data: Volunteers found brief (undefined) exposures to 100 to 260 ppm to be tolerable, although irritating [Schrenk et al. 1933].

Vapor Pressure

0.7 mm Hg

Odor Threshold Low

0.04 ppm

Lethal Concentration

LC50 (rat) = 330 mg/m3/4H

Explanatory Notes

Odor threshold from CHEMINFO;

Reference Link

ATSDR - ToxFAQs - Bis(2-chloroethyl) Ether

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Lacrimator

Yes

Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: