Agent Name

Ethylene thiourea

CAS Number

96-45-7

Formula

C3-H6-N2-S

Major Category

Nitrogen Compounds

Synonyms

1,3-Ethylene-2-thiourea; 1,3-Ethylenethiourea; 2-Imidazolidinethione; 2-Imidazoline-2-thiol; 2-Mercapto-2-imidazoline; 2-Mercaptoimidazoline; 2-Merkaptoimidazolin [Czech]; 2-Thiol-dihydroglyoxaline; 4,5-Dihydro-2-mercaptoimidazole; 4,5-Dihydroimidazole-2(3H)-thione; Akrochem etu-22; Aperochem ETU-22; ETU; Ethylene thiourea; Ethylene thiouree [French]; Ethylenethiourea; Imidazole-2(3H)-thione, 4,5-dihydro-; Imidazolidinethione; Imidazoline, 2-mercapto-; Imidazoline-2(3H)-thione; Imidazoline-2-thiol; Mercaptoimidazoline; Mercazin I; N,N'-Ethylenethiourea; NA-22; NA-22-D; Nocceler 22; Pennac CRA; Rhenogran etu; Rhodanin S 62; Robac 22; Rodanin S-62 [Czech]; Sanceller 22; Sodium-22 neoprene accelerator; Soxinol 22; Tetrahydro-2H-imidazole-2-thione; Thiourea, N,N'-(1,2-ethanediyl)-; Urea, 1,3-ethylene-2-thio-; Vulkacit NPV/C; Vulkacit npv/C2; Warecure C; l'Ethylene thiouree [French]; [ChemIDplus]

Category

Thiourea Compounds

Description

White to pale-green, crystalline solid with a faint, amine odor. [Note: Used as an accelerator in the curing of polychloroprene & other elastomers.]; [NIOSH]

Sources/Uses

The alkylthioureas are used as rubber accelerators; they are also used in insoles, adhesives, wet suits, detergents, plastics, and textiles. [Marks, p. 240] Used in electroplating baths and in the production of antioxidants, insecticides, fungicides, rubber accelerators, dyes, drugs, and resins; [Hawley]

Comments

Potential skin sensitizer; [Marks, p. 240] [Allergic contact dermatitis from ethylene thiourea. Bruze M, Fregert S. Contact Dermatitis 1983;3:208-12] Ethylenethiourea is a common contaminant of ethylene bisdithiocarbamates (Ferbam, Mancozeb, Maneb, Metiram, Nabam, Thiram, Vapam, Ziram, and Zineb). It causes birth defects in high-dose reproductive studies of experimental animals. [Frazier, p. 230-2] May have effects on the thyroid gland and liver; [ICSC] An eye irritant; [CAMEO]

Exposure Assessment
Vapor Pressure

2.02E-6 mm Hg

Explanatory Notes

NIOSH REL = lowest feasible concentration (carcinogen)--use in encapsulated form; Flash point = 486 deg F;

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Not Classifiable

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: