Agent Name

Hexamethylphosphoric triamide

Alternative Name

Hexamethyl phosphoramide

CAS Number

680-31-9

Formula

C6-H18-N3-O-P

Major Category

Other Classes

Synonyms

Eastman Inhibitor HPT; HMPA; HMPT; HMPTA; Hempa; Hexametapol; Hexamethyl phosphoramide; Hexamethylfosforamid [Czech]; Hexamethylorthophosphoric triamide; Hexamethylphosphoramide; Hexamethylphosphoric acid triamide; Hexamethylphosphoric triamide; Hexamethylphosphorotriamide; Hexamethylphosphotriamide; N,N,N,N,N,N-Hexamethylphosphoric triamide; Phosphoric acid hexamethyltriamide; Phosphoric hexamethyltriamide; Phosphoric triamide, hexamethyl-; Phosphoric tris(dimethylamide); Phosphoryl hexamethyltriamide; Tris(dimethylamino)phosphine oxide; Tris(dimethylamino)phosphorus oxide; Tris-(dimethylamid) kyseliny fosforecne [Czech]; [ChemIDplus]

Category

Phosphorus Compounds

Description

Clear, colorless liquid with an aromatic or mild, amine-like odor. [Note: A solid below 43 degrees F.]; [NIOSH]

Sources/Uses

Used as a solvent for aromatic polyamide fibers; also used as a catalyst, stabilizer, and additive for polymers and resins; [ACGIH]

Comments

A TLV is not recommended because the absence of data. Rats suffer kidney injury and death after repeated inhalation exposures. HMPA is carcinogenic in animals. The TLV Basis is upper respiratory tract cancer. [ACGIH] May have effects on the lungs, kidneys, and bone marrow; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Yes

Vapor Pressure

0.03 mm Hg

Lethal Concentration

LCLo (rat) = 2,920 mg/m3/4h

Explanatory Notes

Carcinogen--No TLV; NIOSH REL = lowest feasible conc. Flash point = 222 deg F;

Adverse Effects
Nephrotoxin

Yes

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: