Agent Name

Methylhydrazine

Alternative Name

Methyl hydrazine

CAS Number

60-34-4

Formula

C-H6-N2

Major Category

Toxic Gases & Vapors

Synonyms

Monomethylhydrazine; MMH; Methyl hydrazine; [NIOSH]

Category

Other Toxic Gases & Vapors

Description

Fuming, colorless liquid with an ammonia-like odor; [NIOSH]

Sources/Uses

Used as a rocket fuel, solvent, and chemical intermediate; [ACGIH]

Comments

Liquid causes second or third degree burns after short contact; [CHRIS] Toxic effects resemble those of hydrazine with mucous membrane irritation, methemoglobinemia, hemolytic anemia, and central nervous system injury; [ACGIH] May produce pulmonary edema after high inhalation exposure; [ICSC] In high-dose reproductive studies of animals, hydrazine derivatives (hydrazine, MMH, and UDMH) cause testicular damage and fetal loss, and hydrazine causes birth defects. [Frazier, p. 341-2] Hydrazines antagonize GABA in the CNS causing excitation and seizures. Pyrodoxine, vitamin B6, is a specific antidote for this effect. [AHLS, p. 426]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

TLV (ACGIH)

0.01 ppm

PEL (OSHA)

Ceiling(OSHA) = 0.2 ppm

IDLH (NIOSH)

20 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the report by Jacobson et al. [1955] of a mouse LC50 of 56 ppm. . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

38 mm Hg

Odor Threshold Low

1.7 ppm

Lethal Concentration

LC50 (rat) = 34 ppm/4 hr

Explanatory Notes

1hour SPEGL = 0.24 ppm; [NRC 1985] Odor threshold from CHEMINFO;

Reference Link

ICSC: Methyl hydrazine

Adverse Effects
Toxic Pneumonitis

Yes

Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: