Agent Name

2-Nitropropane

CAS Number

79-46-9

Formula

C3-H7-N-O2

Major Category

Nitrogen Compounds

Synonyms

2-NP; 2-Nitropropane; Dimethylnitromethane; Isonitropropane; Nipar S-20; Nipar S-20 solvent; Nipar S-30 solvent; Nitroisopropane; beta-Nitropropane; [ChemIDplus] UN2608

Category

Nitros, Aliphatic

Description

Colorless liquid with a pleasant, fruity odor; [NIOSH]

Sources/Uses

Used as additive to solvents in concentrations from 5% to 25% to improve drying or flowing characteristics; these solvents are used for coatings, chlorinated rubbers, inks, and adhesives; [ACGIH] "Occupational exposure to 2-NP may occur in many industries including industrial construction and maintenance, printing (rotogravure and flexographic inks), highway maintenance (traffic markings), shipbuilding and maintenance (marine coatings), furniture, and plastic products." [http:www.cdc.gov/niosh/80-142.html]

Comments

Acute liver injury and/or death have been reported in workers 1) painting the interior of a tank, 2) working in confined spaces with paint and polyester-based resin products, and 3) painting epoxy resins on walls. NP-2 induces methemoglobinemia of 15-25% in cats exposed at 280 ppm for 7 hours. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations may cause CNS effects; Exposure above the OEL could cause liver injury and death; [ICSC]

Reference Link

NIOSH Health Hazard Alert-- 2-NP

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 ppm

PEL (OSHA)

25 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Nausea, vomiting, diarrhea, anorexia, and severe headache have been reported in workers exposed to daily concentrations of 20 to 45 ppm [Skinner 1947].

Vapor Pressure

17.2 mm Hg

Odor Threshold Low

81 ppm

Odor Threshold High

288 ppm

Lethal Concentration

LC50 (rat) = 400 ppm/6H

Explanatory Notes

Odor threshold from AIHA; Flash point = 75 deg F;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Primary

Methemoglobinemia

Methemoglobinemia, Secondary

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure:

Activities

Activities with risk of exposure: