Agent Name

Calotropin

CAS Number

1986-70-5

Formula

C29-H40-O9

Major Category

Biological Agents

Synonyms

Card-20(22)-enolide, 14-hydroxy-19-oxo-3,2-((tetrahydro-3,4-dihydroxy-6-methyl-2H-pyran-2,3-diyl)bis(oxy))-, (2alpha(2S,4S,6R),3beta,5alpha)-; Cardenolide; Pecilocerin A; Pekilocerin A; [ChemIDplus]

Category

Plant Toxins

Description

Solid; Soluble in water; [Merck Index]

Sources/Uses

African arrow poison isolated from milk sap of Calotropis procera; [Merck Index]

Comments

Emergency treatment: "Plants- cardiac glycosides"; [HSDB] Intraperitoneal LD50 (mouse) = 9800 ug/kg; Causes ataxia, somnolence, and seizures at lethal doses; [RTECS] Milkweed (Asclepias spp) contains cardiac glycosides; [Olson, p. 344] Milkweed (Asclepias spp) contains cardenolides that are cardiac toxins; [Goldfrank, p. 1538] See "Calotoxin."

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

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