Agent Name

Propyleneimine

Alternative Name

2-Methylaziridine

CAS Number

75-55-8

Formula

C3-H7-N

Major Category

Nitrogen Compounds

Synonyms

1,2-Propyleneimine; 1,2-Propylenimine; 2-Methylazacyclopropane; 2-Methylaziridine; 2-Methylethylenimine; Aziridine, 2-methyl-; Methylaziridine; Methylethylenimine; Propilenimina [Spanish]; Propylene imine; Propyleneimine; Propylenimine; [ChemIDplus] UN1921

Category

Other Nitrogen Compounds

Description

Colorless, oily liquid with an ammonia-like odor; [NIOSH]

Sources/Uses

Used as an intermediate in the rubber and pharmaceutical industries; Used as a modifier and monomer in advanced composites; [HSDB]

Comments

At higher concentrations, may cause blistering and necrosis of the skin; Toxicity is similar to that of ethyleneimine; Causes severe injuries to the kidneys (tubular necrosis) in acute animal experiments and tumors in chronic ones; [HSDB] An irritant of the the skin, eyes, and respiratory tract; [ICSC] Suspected germ cell mutagen (3B); [MAK] Propyleneimine, stabilized (UN1921) has warning of explosive polymerization; [ERG 2016]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.2 ppm

STEL (ACGIH)

0.4 ppm

PEL (OSHA)

2 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

It has been reported that rats survived a 2hour exposure to 500 ppm and guinea pigs survived a 30minute exposure to 500 ppm [Carpenter et al. 1948].

Vapor Pressure

112 mm Hg

Lethal Concentration

LCLo (rat) = 500 ppm/4 hr

Explosive Polymerization

Yes

Explanatory Notes

Flash point = -3 deg C;

Adverse Effects
Toxic Pneumonitis

Yes

Nephrotoxin

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Possible Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: