Agent Name


CAS Number




Major Category



Acarithion; Akarithion; Carbofenothion [Dutch]; Carbofenotion; Carbofenotionum [INN-Latin]; Carbofenthion; Carbophenothion; Dagadip; Dithiophosphate de O,O-diethyle et de (4-chloro-phenyl) thiomethyle [French]; ENT 23,708; Endyl; Ethyl carbophenothion; Garrathion; Hexathion; Karbofenothion [Czech]; Lethox; Nephocarp; O,O-Diaethyl-S-((4-chlor-phenyl-thio)-methyl)dithiophosphat [German]; O,O-Diethyl S-(4-chlorophenylthiomethyl) dithiophosphate; O,O-Diethyl S-(p-chlorophenylthiomethyl) phosphorodithioate; O,O-Diethyl S-p-chlorophenylthiomethyl dithiophosphate; O,O-Diethyl dithiophosphoric acid p-chlorophenylthiomethyl ester; O,O-Diethyl p-chlorophenylmercaptomethyl dithiophosphate; O,O-Diethyl-S-((4-chloor-fenyl-thio)-methyl)-dithiofosfaat [Dutch]; O,O-Diethyl-S-p-chlorfenylthiomethylester kyseliny dithiofosforecne [Czech]; O,O-Dietil-S-((4-cloro-fenil-tio)-metile)-ditiofosfato [Italian]; OMS 244; Oleoakarithion; Phosphorodithioic acid, S-(((4-chlorophenyl)thio)methyl) O,O-diethyl ester; Phosphorodithioic acid, S-(((p-chlorophenyl)thio)methyl) O,O-diethyl ester; R 1303; R-1303; S-(((4-Chlorophenyl)thio)methyl) O,O-diethyl phosphorodithioate (9CI); S-((p-Chlorophenylthio)methyl) O,O-diethyl phosphorodithioate; S-(4-Chlorophenylthiomethyl)diethyl phosphorothiolothionate; Stauffer R-1,303; Trithion; Trithion miticide; [ChemIDplus] UN3018


Organophosphate Insecticides


Colorless or light amber liquid; [HSDB] Slight odor of rotten eggs; [CAMEO] Clear liquid; [MSDSonline]


Used as a non-systemic acaricide and insecticide for citrus, deciduous fruits and nuts, and other crops; [HSDB]


May be absorbed through skin; A cholinesterase inhibitor; [ICSC] In an epidemic involving 19 sugar cane workers, the route of exposure appeared to be inhalation or skin absorption (possibly both); Animal feeding studies showed depression of cholinesterase activity but no gross or microscopic pathology; [HSDB] A highly toxic cholinesterase inhibitor (estimated lethal oral dose of 0.6 g for 70 kg person); [CAMEO] Effects in a three-generation feeding study with rats at 20 ppm include reduced pup weight, increase in stillbirths, and fewer pups alive at weaning; Examination of stillborn pups was negative for teratogenicity; Effects in a 2 year feeding study with rats at the highest dose level (80 ppm) include an increase in adrenal weight; No increase in incidence of neoplasm was observed; [INCHEM JMPR] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]


Cancelled--no longer registered as a pesticide for use in the US; [HSDB]

Exposure Assessment

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Vapor Pressure

3.0E-7 mm Hg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticides, liquid, toxic."

Adverse Effects
Other Poison


Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

Search ChemIDplus

Related Information in HazMap

Occupational diseases associated with exposure to this agent:


Industrial Processes with risk of exposure: