Agent Name

p-Toluenesulfonyl chloride

CAS Number

98-59-9

Formula

C7-H7-Cl-O2-S

Major Category

Toxic Gases & Vapors

Synonyms

4-Methylbenzenesulfonyl chloride; 4-Toluenesulfonic acid, chloride; 4-Toluenesulfonyl chloride; Benzenesulfonyl chloride, 4-methyl-; Toluenesulfonyl chloride (VAN); Tosyl chloride; p-Methylbenzenesulfonyl chloride; p-Toluenesulfochloride; p-Toluenesulfonic acid chloride; p-Toluenesulphonyl chloride; p-Tolylsulfonyl chloride; p-Tosyl chloride; para-Toluenesulfochloride; para-Toluenesulfonyl chloride; [ChemIDplus] PTSC; [AIHA] UN3096

Category

Acid Halides

Description

A white to gray solid; [CAMEO] Hygroscopic; [eChemPortal: SIDSUNEP] White or light yellow crystalline solid; [MSDSonline]

Sources/Uses

Used to make other organic chemicals; [Hawley] Used to make food additives, foaming agents for plastics and rubber, riboflavin, antithrombotic drugs, and dye condensing agents; [eChemPortal: SIDSUNEP]

Comments

A skin, eye, and respiratory tract irritant; [HSDB] Reacts violently with water evolving hydrochloric acid; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; [MSDSonline] Slowly hydrolyzes to strong acids (HCl and p-toluenesulfonic acid); Severely irritating to skin and eyes in animal testing; [AIHA] Contact dermatitis documented in a chemist; [Kanerva, p. 1841]

Reference Link

Occupational contact dermatitis from tosyl chlorid... [Contact Dermatitis. 1993] - PubMed result

Exposure Assessment
WEEL

Ceiling = 5 mg/m3

Explanatory Notes

VP = 0.5 mm Hg at 75 deg C; [ChemIDplus] The Guide in the Emergency Response Guidebook is for "Corrosive solid, water-reactive, n.o.s."

Adverse Effects
Skin Sensitizer

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: