Agent Name

Chlormephos

CAS Number

24934-91-6

Formula

C5-H12-Cl-O2-P-S2

Major Category

Pesticides

Synonyms

Chlormefos; Chlormethylfos; Dotan; MC 2188; Phosphorodithioic acid, S-(chloromethyl) O,O-diethyl ester; S-(Chloromethy) O,O-diethyl phosphorodithioate; S-(Chloromethyl) O,O-diethylphosphorodithioate; S-Chloromethyl O,O-diethyl phosphorodithioate; S-Chloromethyl-O,O-diethylphosphorothiolothionate; [ChemIDplus] UN3018

Category

Organophosphate Insecticides

Description

Water-white liquid; [Merck Index] Colorless liquid; [ICSC]

Sources/Uses

Used as insecticide applied to soil; [Merck Index]

Comments

A non-systemic cholinesterase inhibitor; [Merck Index] May be absorbed through skin; A cholinesterase inhibitor; [ICSC] The average of two baseline respective cholinesterase activity determinations three days apart, with no exposures to enzyme inhibiting pesticides for at least 30 days, is recommended for each worker prior to exposure to cholinesterase inhibitors because of large inter-individual differences in published baseline values. To be established at least once a year. Removal from workplace exposures is recommended until the cholinesterase activity returns to within 20% of baseline. [TLVs and BEIs]

Restricted

Not registered as a pesticide for use in the US; [CAMEO] Banned in the EU for use as a biocide and agricultural insecticide; [eChemPortal: ESIS]

Exposure Assessment
BEI

Acetylcholinesterase activity in red blood cells = 70% of individual's baseline; Butylcholinesterase activity in serum or plasma = 60% of individual's baseline; Sample at end of shift; [TLVs and BEIs]

Lethal Concentration

LC50 (rat) = 88 mg/m3/4h

Explanatory Notes

VP = 0.057 mm Hg at 30 deg C; [Merck Index] The Guide in the Emergency Response Guidebook is for "Organophosphorus pesticide, liquid, toxic."

Adverse Effects
Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: