Agent Name

o-Toluidine

CAS Number

95-53-4

Formula

C7-H9-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-2-methylbenzene; 1-Methyl-2-aminobenzene; 2-Amino-1-methylbenzene; 2-Aminotoluene; 2-Methyl-1-aminobenzene; 2-Methylaniline; 2-Methylbenzamine; 2-Methylbenzenamine; 2-Toluidine; Aniline, 2-methyl-; C.I. 37077; o-Aminotoluene; o-Methylaniline; o-Methylbenzenamine; o-Toluidin [Czech]; o-Toluidine; o-Toluidyna [Polish]; o-Tolylamine; [ChemIDplus] UN1708

Category

Amines, Aromatic

Description

Colorless to pale-yellow liquid with an aromatic, aniline-like odor; [NIOSH]

Sources/Uses

An intermediate used in the organic synthesis of dyes, pharmaceuticals, and other chemicals; [ACGIH]

Comments

Methemoglobinemia, bladder irritation, and hematuria have been reported in exposed workers. Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] May cause methemoglobinemia and kidney injury; [ICSC]

Reference Link

IARC 2012: ortho-Toluidine

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

2 ppm

PEL (OSHA)

5 ppm

IDLH (NIOSH)

50 ppm

Excerpts from Documentation for IDLHs

Human data: It has been reported that a 60­minute exposure to 40 ppm produces severe toxic effects [Goldblatt 1955]. It has been reported that 100 ppm is the maximum concentration endurable for 1 hour without serious consequences [Sax 1975].

Vapor Pressure

0.3 mm Hg

Odor Threshold Low

0.02 ppm

Odor Threshold High

6.6 ppm

Lethal Concentration

LC50 (rat) = 862 ppm/4h

Explanatory Notes

Odor threshold from AIHA; Flash point = 185 deg F;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Nephrotoxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Anemia

Anemia, Hemolytic

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Human Carcinogen

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Activities

Activities with risk of exposure: