Agent Name

Chlorpyrifos-methyl

Alternative Name

Chlorpyrifos O,O-dimethyl analog

CAS Number

5598-13-0

Formula

C7-H7-Cl3-N-O3-P-S

Major Category

Pesticides

Synonyms

Chlorpyrifos O,O-dimethyl analog; Chloropyriphos-methyl; Chlorpyrifos methyl; Chlorpyriphos-methyl [ISO-French]; Dowco 214; Dursban methyl; ENT 27520; M 3196; Methyl chlorpyrifos; Methyl chlorpyriphos; Methyl dursban; Methylchlorpyrifos; Noltran; O,O-Dimethyl O-(3,5,6-trichloro-2-pyridinyl) phosphorothioate (8CI)(9CI); O,O-Dimethyl O-(3,5,6-trichloro-2-pyridyl)phosphorothioate; O,O-Dimethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate; OMS-1155; Reldan; Reldan 50 EC; Trichlormethylfos; Tumar; Zertell; [ChemIDplus]

Category

Organophosphate Insecticides

Description

White or amber solid; [HSDB] Colorless solid; [CAMEO]

Sources/Uses

Used as insecticide, acaricide, and veterinary ectoparasiticide; [Merck Index] Used mainly to protect cereals (including storage); [HSDB] Used as insecticide for stored grains, rice, oil crops, and animal feed; [Reference #1]

Comments

A skin irritant; [SAX] May cause skin sensitization; [eChemPortal: ESIS] In a two year feeding study with rats (highest dose level 1 mg/kg/day) no significant adverse gross or histopathological changes were observed as well as no relation to frequency of spontaneous tumors; Effects in a three generation feeding study with rats include inhibition of cholinesterase activity and decreased pup weights in the second and third generation; No significant effects were observed in fertility, gestation, viability, or lactation; No gross or histopathological changes were noted in third generation parental animals; No teratogenic effects observed in a study with rats; [Reference #2] See "Chlorpyrifos."

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Vapor Pressure

4.22E-5 mm Hg

Lethal Concentration

LC50 (rat) > 670 mg/m3/4h

Reference Link

INCHEM JMPR: Chlorpyrifos-methyl

Adverse Effects
Other Poison

Organophosphate

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: