Agent Name

p-Toluidine

CAS Number

106-49-0

Formula

C7-H9-N

Major Category

Nitrogen Compounds

Synonyms

1-Amino-4-methylbenzene; 4-Amino-1-methylbenzene; 4-Aminotoluen [Czech]; 4-Aminotoluene; 4-Methylaniline; 4-Methylbenzenamine; 4-Toluidine; Aniline, p-methyl-; Benzenamine, 4-methyl-; C.I. 37107; C.I. Azoic Coupling Component 107; CI 37107; CI Azoic Coupling Component 107; Naphtol AS-KG; Naphtol AS-KGLL; Toluidine, p-; p-Aminotoluene; p-Methylaniline; p-Methylbenzenamine; p-Toluidin [Czech]; p-Toluidyna [Polish]; p-Tolylamine; [ChemIDplus] UN1993

Category

Amines, Aromatic

Description

White solid with an aromatic odor. [Note: Used as a basis for many dyes.]; [NIOSH]

Sources/Uses

Intermediate used in the organic synthesis of dyes, reagents, and other chemicals; [ACGIH]

Comments

Solid form causes first degree burns on short exposure; [CHRIS] "In the United Kingdom between 1961 and 1980, chloroaniline, p-toluidine, nitrobenzene, and nitrochlorobenzene were the most common industrial causes of methemoglobinemia. Dermal exposure was a more frequent route of toxicity than inhalation with these compounds." [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988.] Listed in the table "Examples of Industrial Chemicals for Which Methemoglobin Formation is NOT the Principal Cause of Toxicity"; [ACGIH] May cause methemoglobinemia and kidney injury; A potential skin sensitizer; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

2 ppm

Vapor Pressure

0.28 mm Hg

Odor Threshold Low

0.02 ppm

Odor Threshold High

3.2 ppm

Lethal Concentration

LC50 (rat) > 640 mg/m3/1h

Explanatory Notes

Odor threshold from AIHA; Flash point = 87 deg C;

Reference Link

ICSC: p-Toluidine

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Confirmed Animal

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Activities

Activities with risk of exposure: