Agent Name

1,2,3-Trichloropropane

CAS Number

96-18-4

Formula

C3-H5-Cl3

Major Category

Solvents

Synonyms

1,2,3-Trichloropropane; Allyl trichloride; Glycerol trichlorohydrin; Glyceryl trichlorohydrin; Trichlorohydrin; Trichloropropane; [ChemIDplus] UN2810

Category

Chlorinated Aliphatics

Description

Colorless liquid with a chloroform-like odor; [NIOSH]

Sources/Uses

Used as a curing agent for polysulfides and a chemical intermediate; Used in the past as a solvent and extractive agent; [ACGIH] Used as a degreaser, paint remover, and solvent for resins, waxes, and oils; [HSDB]

Comments

Mice have hepatic damage and die after exposure to 5000 ppm for 20 minutes. Rats and guinea pigs have CNS depression after exposures to 800, 2100, or 5000 ppm for 30 minutes. Workers complained of unpleasant odor and irritation of the eyes and throat at 100 ppm. TLV Basis is cancer. [ACGIH] A skin, eye, and respiratory tract irritant; May cause liver and kidney injury; Inhalation of high concentrations can cause CNS depression; [ICSC]

Exposure Assessment
TLV (ACGIH)

0.005 ppm

PEL (OSHA)

50 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

It has been reported that objectionable ocular and mucosal irritation were experienced after 15 minutes of exposure to 100 ppm [Silverman et al. 1946].

Vapor Pressure

3 mm Hg

Odor Threshold Low

100 ppm

Lethal Concentration

LCLo (rat) = 500 ppm/4H

Explanatory Notes

Odor threshold from "Quick Guide: The Electronic NIOSH Pocket Guide to Chemical Hazards"; Flash point = 180 deg F;

Half Life

Animal studies (whole body): 1 day; [TDR, p. 1194]

Reference Link

ATSDR - ToxFAQs - 1,2,3-Trichloropropane

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

ACGIH Carcinogen

Suspected Human

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: