Agent Name

Citral

CAS Number

5392-40-5

Formula

C10-H16-O

Major Category

Biological Agents

Synonyms

2,6-Dimethyloctadien-2,6-al-8; 2,6-Octadienal, 3,7-dimethyl-; 3,7-Dimethyl-1,2,6-octadienal; 3,7-Dimethyl-2,6-octadienal; Citral (natural); Lemsyn GB; [ChemIDplus]

Category

Plant Oils and Extracts

Description

Pale yellow liquid with a strong odor of lemon; [Merck Index] Colorless liquid; [MSDSonline]

Sources/Uses

Component of many commercial oils including lemon grass, verbena, lemon, and orange; [Merck Index] Used as a flavoring agent and fragrance and an intermediate for the synthesis of other fragrances, vitamin A, ionone, and methylinone; [HSDB]

Comments

A skin irritant; May be absorbed through skin; Emergency treatment: "Lemon grass oil"; Citral, the main component, causes liver injury in high-dose animal experiments; Citral in concentrations >8% can cause irritation or allergic dermatitis; [HSDB] A blend of Neral and Geranial; [Kanerva, p. 1771] TLV based on high-dose animal studies showing body weight effects, upper respiratory tract irritation, and eye damage; A skin sensitizer based on patch testing in humans: about 1% of patients with hand dermatitis have positive patch tests to 2% citral; [ACGIH] Included in list of "established contact allergens in humans"; [ToxPlanet: EC: Scientific Committee on Consumer Safety: Fragrance allergens in cosmetic products (2011)] Effects in high-dose animal studies include somnolence and changes in the liver and kidneys; [RTECS] A skin and mucous membrane irritant; May cause skin sensitization; [Aldrich MSDS]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm, inhalable fraction and vapor

Vapor Pressure

0.09 mm Hg

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: