Agent Name

o-Dichlorobenzene

Alternative Name

1,2-Dichlorobenzene

CAS Number

95-50-1

Formula

C6-H4-Cl2

Major Category

Solvents

Synonyms

1,2-Dichlorobenzene; Chloroben; Cloroben; DCB; Dichlorobenzene, ortho, liquid; Dilantin DB; Dilatin DB; Dizene; Dowtherm E; Orthodichlorobenzene; Orthodichlorobenzol; Special termite fluid; Termitkil; o-Dichlor benzol; o-Dichlorbenzol; o-Dichlorobenzene; o-Dichlorobenzol; [ChemIDplus] UN1591

Category

Chlorinated Aromatics

Description

Colorless to pale-yellow liquid with a pleasant, aromatic odor.(herbicide); [NIOSH]

Sources/Uses

Used as a chemical intermediate, solvent, heat transfer liquid, deodorant, and insecticide; [ACGIH] Used as a degreasing agent, a paint solvent, paint remover, a cylinder lubricant, and a solvent for waxes, gums, resins, tars, rubber, oils, and asphalts; [HSDB]

Comments

Liver and kidney injury occur in animal inhalation studies. Inhalation of saturated vapor by mice results in narcosis and death. A case of skin sensitization reported, but "sufficient data were not available to recommend a SEN notation." [ACGIH] Inhalation of high concentrations may cause CNS effects; A skin, eye, and respiratory tract irritant; [ICSC]

Restricted

Cancelled: no registered pesticide products in the USA; [HSDB]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

25 ppm

STEL (ACGIH)

50 ppm

PEL (OSHA)

Ceiling(OSHA) = 50 ppm

MAK

10 ppm

IDLH (NIOSH)

200 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by ACGIH [1971] that 1,000 ppm was fatal to guinea pigs after 20 hours [Browning 1953]. ACGIH [1971] also reported that Cameron et al. [1937] found liver damage in animals after exposure for a few hours at 50 to 800 ppm. . . . Human data: Concentrations up to 100 ppm have been reported to have caused sporadic irritation of the eyes and respiratory tract [Elkins 1959].

Vapor Pressure

1.36 mm Hg

Odor Threshold Low

0.02 ppm

Odor Threshold High

50 ppm

RD50

182 ppm

Lethal Concentration

LCLo (rat) = 821 ppm/7H

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.70 ppm); Flash point = 151 deg F;

Reference Link

ICSC: 1,2-Dichlorobenzene

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: