Agent Name

Dichloromonofluoromethane

Alternative Name

Dichlorofluoromethane

CAS Number

75-43-4

Formula

C-H-Cl2-F

Major Category

Solvents

Synonyms

Algofrene type 5; Arcton 7; CFC-21; Dichlorofluoromethane; Dichloromonofluoromethane; Dwuchlorofluorometan [Polish]; F 21; FC-21; Fluorocarbon 21; Fluorodichloromethane; Freon 21; Freon F 21; Genetron 21; HCFC 21; Halon 112; Methane, dichlorofluoro-; Monofluorodichloromethane; R 21 (refrigerant); Racon 21; Refrigerant 21; [ChemIDplus] UN1029

Category

Chlorofluorocarbons

Description

Colorless gas with a slight, ether-like odor; Note: A liquid below 48 degrees F. Shipped as a liquefied compressed gas; [NIOSH]

Sources/Uses

CFC-21 has been used as a solvent, refrigerant, and propellant. [ACGIH]

Comments

See "CHLOROFLUOROCARBONS"; Possible frostbite from contact with liquid; [NIOSH] Inhalation of high concentrations may cause CNS effects; [ICSC] "The substance may have effects on the liver." [ICSC]

Restricted

See CHLOROFLUOROCARBONS

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 ppm

PEL (OSHA)

1000 ppm

MAK

10 ppm

IDLH (NIOSH)

5000 ppm

Excerpts from Documentation for IDLHs

In 5minute cardiac sensitization screening tests, 2 of 12 unanesthetized dogs exposed to 10,000 ppm of dichloromonofluoromethane plus intravenous epinephrine showed evidence of serious arrhythmia; no response was noted at 5,000 ppm [Mullin 1975].

Lethal Concentration

LC50 (rat) = 49,900 ppm/4H

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Other Poison

Simple Asphyxiant

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: