Agent Name

Cocaine

CAS Number

50-36-2

Formula

C17-H21-N-O4

Major Category

Biological Agents

Synonyms

"C" Carrie; (1R,2R,3S,5S)-2-Methoxycarbonyltropan-3-yl benzoate; 1-Cocaine; 1-alpha-H,5-alpha-H-Tropane-2-beta-carboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate; 2-beta-Carbomethoxy-3-beta-benzoxytropane; 2-beta-Tropanecarboxylic acid, 3-beta-hydroxy-, methyl ester, benzoate (ester); 2beta-Carbomethoxy-3beta-benzoxytropane; 3-(Benzoyloxy)-8-methyl-8-azabicyclo-(3.2.1)octane-2-carboxylic acid methyl ether; 3-Tropanylbenzoate-2-carboxylic acid methyl ester; 3beta-Hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylic acid methyl ester benzoate; 8-Azabicyclo(3.2.1)octane-2-carboxylic acid, 3-(benzoyloxy)-8-methyl-, methyl ester, (1R-(exo,exo))-; Benzoylmethylecgonine; Bernice; Bernies; Blow; Burese; Cecil; Cholly; Cocaina; Cocaine, l-; Coke; Corine; Crack; Crack cocaine; Dama blanca; Ecgonine, methyl ester, benzoate (ester); Eritroxilina; Erytroxylin; Flake; Girl; Gold dust; Green gold; Happy dust; Happy trails; Her; Jam; Kokain; Kokan; Kokayeen; L-Cocaine; Lady; Leaf; Methyl 3-beta-hydroxy-1-alpha-H,5-alpha-H-tropane-2-beta-carboxylate benzoate (ester); Methyl 3beta-hydroxy-1alphaH,5alphaH-tropane-2beta-carboxylate benzoate (ester); Methyl Benzoylecgonine; Neurocaine; Nose candy; Pimp's drug; Rock; Snow; Star dust; Star-spangled powder; Toot; White girl or lady; [ChemIDplus]

Category

Plant Toxins

Description

Colorless to white solid; [Hawley]

Sources/Uses

Extracted from the leaves of coca shrubs indigenous to South America; Used as local anesthetic (nasal and ophthalmic) and vasoconstrictor for otolaryngology procedures; [HSDB] Used as a controlled substance in medicine and dentistry, usually as the hydrochloride compound; [Hawley] A popular drug of abuse; [Olson, p. 201]

Comments

CNS effects may include euphoria, delirium, agitation, muscle hyperactivity, and seizures. Cardiac effects may include arrhythmias, hypertension, hemorrhagic stroke, coronary artery spasm, and myocardial infarction. Death from overdose is usually due to fatal arrhythmias, status epilepticus, stroke, or hyperthermia. [Olson, p. 202-3] Use of cocaine during pregnancy is associated with premature birth, behavioral abnormalities of offspring, and possibly congenital anomalies of the urinary tract; [REPROTOX]

Exposure Assessment
Vapor Pressure

1.91E-7 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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