Agent Name

Convallatoxin

CAS Number

508-75-8

Formula

C29-H42-O10

Major Category

Biological Agents

Synonyms

3beta-((6-Deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-5beta-card-20(22)-enolide; Card-20(22)-enolide, 3-((6-deoxy-alpha-L-mannopyranosyl)oxy)-5,14-dihydroxy-19-oxo-, (3beta,5beta)-; Convallaotoxin; Convallaton; Convallatoxoside; Convallotoxin; Corglycon; Corglycone; Corglykon; Korglykon; Mannopyranoside, strophanthidin-3,6-deoxy-, alpha-L-; Rhamnoside, strophanthidin-3, alpha-L-; Strophanthidin alpha-L-rhamnoside; Strophanthidin, 3-(6-deoxy-alpha-L-mannopyranoside); [ChemIDplus]

Category

Plant Toxins

Description

Solid; [Merck Index]

Sources/Uses

Naturally occurring in lily of the valley blossoms; Used as a cardiotonic and veterinary diuretic; [Merck Index]

Comments

Emergency treatment: "Cardiac glycosides"; [HSDB] A review of 2693 lily of the valley exposures (93% children) found no fatalities with only 3 patients suffering a major outcome.[Ford, p. 924] Acute overdose of cardiac glycosides can cause vomiting, hyperkalemia, and arrhythmias. Chronic poisoning can cause visual disturbances, weakness, and arrhythmias. [Olson, p. 222-3] Oral LD50 (mouse) >2000 mg/kg; [RTECS] May cause irritation; Targets the cardiovascular system; [MSDSonline]

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