Agent Name

Cucurbitacin B

CAS Number

6199-67-3

Formula

C32-H46-O8

Major Category

Biological Agents

Synonyms

1,2-Dihydro-alpha-elaterin; 19-Nor-9beta,10alpha-lanosta-5,23-diene-3,11,22-trione, 2beta,16alpha,20,25-tetrahydroxy-9-methyl-, 25-acetate; 19-Norlanosta-5,23-diene-3,11,22-trione, 25-(acetyloxy)-2,16,20-trihydroxy-9-methyl-, (2beta,9beta,10alpha,16alpha,23E)-; 25-(Acetyloxy)-2,16,20-trihydroxy-9-methyl-19-norlanosta-5,23-diene-3,11,22-trione; Amarine; CUCURBITACIN R - DATISCA PRINCIPLE B; Cucurbitacine B; DATISCACIN; Datisca principle B; Datiscn Principle B; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [Merck Index]

Sources/Uses

Cucurbitacins: Isolated from cucurbitaceous plants and used as vermifuges, emetics, narcotics, and antimalarials; Reported cause of livestock poisoning in South Africa; [Merck Index] Highly toxic substance in wild cucumbers; [HSDB]

Comments

Marked laxative effects in mice given 5 mg/kg orally; Bind to glucocorticoid receptors and have cytolytic and antitumor activity; [HSDB] Oral LD50 (mouse) = 14 mg/kg; [RTECS]

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