Agent Name

Cucurbitacin C

CAS Number

5988-76-1

Formula

C32-H48-O8

Major Category

Biological Agents

Synonyms

19-Nor-9-beta,10-alpha-lanosta-5,23-diene-11,22-dione, 3-beta,16-alpha,20,25-tetrahydroxy-9-(hydroxymethyl)-, 25-acetate; 19-Nor-9beta,10alpha-lanosta-5,23-diene-11,22-dione, 3beta,16alpha,20,25-tetrahydroxy-9-(hydroxymethyl)-, 25-acetate; 19-Norlanosta-5,23-diene-11,22-dione, 25-(acetyloxy)-3,16,20-trihydroxy-9-(hydroxymethyl)-, (3beta,9beta,10alpha,16alpha,23E)-; 25-(Acetyloxy)-3,16,20-trihydroxy-9-(hydroxymethyl)-19-norlanosta-5,23-diene-11,22-dione; Cucurbitacine C; [ChemIDplus]

Category

Plant Toxins

Description

Solid; [HSDB]

Sources/Uses

Cucurbitacins: Isolated from cucurbitaceous plants and used as vermifuges, emetics, narcotics, and antimalarials; Reported cause of livestock poisoning in South Africa; [Merck Index] Highly toxic substance in wild cucumbers; [HSDB]

Comments

Marked laxative effects in mice given 5 mg/kg orally; Bind to glucocorticoid receptors and have cytolytic and antitumor activity; [HSDB] Oral LD50 (mouse) = 100 mg/kg; [RTECS]

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