Agent Name

2-Diethylaminoethanol

CAS Number

100-37-8

Formula

C6-H15-N-O

Major Category

Nitrogen Compounds

Synonyms

(2-Hydroxyethyl)diethylamine; 2-(Diethylamino)ethanol; 2-(Diethylamino)ethyl alcohol; 2-(N,N-Diethylamino)ethanol; 2-Hydroxytriethylamine; 2-N-Diethylaminoethanol; DEAE; Diaethylaminoaethanol [German]; Diethyl(2-hydroxyethyl)amine; Diethylethanolamine; Diethylmonoethanolamine; Ethanol, 2-(diethylamino)-; N,N-Diethyl-2-aminoethanol; N,N-Diethyl-2-hydroxyethylamine; N,N-Diethyl-N-(beta-hydroxyethyl)amine; N,N-Diethylethanolamine; N,N-Diethylmonoethanolamine; N-Diethylaminoethanol; Pennad 150; beta-Diethylaminoethanol; beta-Diethylaminoethyl alcohol; beta-Hydroxytriethylamine; [ChemIDplus] UN2686

Category

Ethanolamines

Description

Colorless liquid with a nauseating, ammonia-like odor; [NIOSH]

Sources/Uses

Used as an isocyanate curing agent; [Sullivan, Table 34-2, p. 471] Used as a chemical intermediate for pharmaceuticals, cosmetics, flocculants, emulsifiers, surface coatings, and other organic chemicals (in the chemical, agricultural, plastics, paper, and leather industries); [HSDB]

Comments

Corrosive to skin; [Quick CPC] Possible cause of asthma; [Reference #1] Causes upper and lower respiratory tract irritation; Rats show signs of upper respiratory irritation with exposures above 120 mg/m3; [NIOSH Criteria Document] May cause allergic contact dermatitis; [CAMEO] Corrosive to the eyes; [ICSC]

Reference Link

New-onset asthma after exposure to the steam system additive 2-diethylaminoethanol. A descriptive study

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

2 ppm

PEL (OSHA)

10 ppm

MAK

5 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Human data: A very short exposure (<30 seconds) to a concentration estimated to be less than 100 ppm has resulted in nausea and vomiting within 5 minutes; other persons in the same room also complained of the nauseating odor but did not become ill [Cornish 1965].

Vapor Pressure

1.4 mm Hg

Odor Threshold Low

0.01 ppm

Lethal Concentration

LCLo (rat) = 4,500 mg/m3/4H

Explanatory Notes

Detection odor threshold from AIHA (mean = 0.011 ppm); Flash point = 49 deg C; VP = 21 mm Hg @ 20 deg C; [HSDB]

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: