Agent Name

Cycloheximide

CAS Number

66-81-9

Formula

C15-H23-N-O4

Major Category

Pesticides

Synonyms

(1S-(1alpha(S*),3alpha,5beta))-4-(2-(3,5-Dimethyl-2-oxo-cyclohexyl))-2-hydroxyethyl-2,6-piperidinedione; 2,6-Piperidinedione, 4-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-, (1S-(1alpha(S*),3alpha,5beta))-; 3-(-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide; 3-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide; 3-(2R)-2-((1S,3S,5S)-3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethylglutarimide; 4-((2R)-2-((1S,3S,5S)-(3,5-Dimethyl-2-oxocyclohexyl))-2-hydroxyethyl)piperidine-2,6-dione; Acti-Aid; Acti-Dione; Actidion; Actidione BR; Actidione PM; Actidione TGF; Actidone; Actispray; Aktidion [Czech]; CBC 500046; CX; Cicloheximida [INN-Spanish]; Cicloheximide; Cicloheximidum [INN-Latin]; Glutarimide, 3-(2-(3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-; Hizarocin; Kaken; Naramycin; Naramycin A; Neocycloheximide; TZA; U 4527; U-4527; beta-(2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)glutarimide; [ChemIDplus] UN2588

Category

Plant Growth Regulators

Description

Colorless solid; [ICSC] White to beige powder; [MSDSonline]

Sources/Uses

Antibiotic compound isolated from Streptomyces griseus; [Merck Index] Used as a fungicide, plant growth regulator, protein synthesis inhibitor, and to stimulate the natural abscission process (pre-harvest use on citrus); [HSDB]

Comments

A skin and eye irritant; May be very toxic by ingestion; [ICSC] A skin irritant; At lethal doses, causes bloody diarrhea, tremors, excitement, coma, and cardiovascular collapse; LD50 = 500 mg/kg in monkeys and dogs, but only 2 mg/kg in rats; [HSDB] Extremely toxic (probable oral lethal dose in humans is 5-50 mg/kg, or 7 drops to 1 teaspoonful for a 150-lb. person); [CAMEO] An irritant; May cause skin sensitization; May cause damage to liver and spleen, and have effects on the blood; [MSDSonline] Toxic to embryo of mice at a maternal dose of 30 mg/kg; Inhibits maturation of amphibian spermatocytes; [REPROTOX]

Exposure Assessment
Vapor Pressure

4.45E-13 mm Hg

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Processes

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