Agent Name

Cyclophosphamide

CAS Number

50-18-0

Formula

C7-H15-Cl2-N2-O2-P

Major Category

Other Classes

Synonyms

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin; 2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; ASTA B518; B 518; Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester; CB 4564; Ciclofosfamida [INN-Spanish]; Ciclophosphamide [INN]; Clafen; Claphene; Cyclophosphamid; Cyclophosphamidum [INN-Latin]; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclophosphoramide; Cyclostin; Cyklofosfamid [Czech]; Cytophosphan; Cytophosphane; Cytoxan; Endoxan; Endoxan R; Endoxan-asta; Endoxana; Endoxanal; Genoxal; Lyophilized cytoxan; N,N-Bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide; N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide; N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide; N,N-Bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide; N,N-Bis-(beta-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid [German]; N,N-Di(2-chloroethyl)-N,O-propylene-phosphoric acid ester diamide; Neosar; Occupation, cyclophosphamide exposure; Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, intramol. Ester; Procytox; SK 20501; Sendoxan; Zyklophosphamid [German]; [ChemIDplus]

Category

Other Organic Compounds

Description

White odorless solid; Liquefies upon loss of crystallization water; Darkens on light exposure; [ICSC] White odorless crystalline solid; [MSDSonline]

Sources/Uses

Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug; [Merck Index] An alkylating agent; [HSDB]

Comments

A skin, eye, and respiratory tract irritant; May cause effects on the blood, bladder, CNS, lungs, and heart; Carcinogenic to humans and may cause reproductive toxicity and heritable genetic damage; [ICSC] A severe skin irritant; Common side effects at therapeutic doses include alopecia, sterility, gastrointestinal disturbances, thrombocytopenia, anemia, leukopenia, and life-threatening hemorrhagic cystitis; Rare side effects include hepatitis, interstitial pneumonitis, and pulmonary fibrosis; Teratogenic; [HSDB] May cause serious eye injury; Can be absorbed through skin; [MSDSonline]

Exposure Assessment
Vapor Pressure

4.45E-5 mm Hg

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.