Agent Name


CAS Number




Major Category

Other Classes


1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin; 2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide; ASTA B518; B 518; Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester; CB 4564; Ciclofosfamida [INN-Spanish]; Ciclophosphamide [INN]; Clafen; Claphene; Cyclophosphamid; Cyclophosphamidum [INN-Latin]; Cyclophosphan; Cyclophosphane; Cyclophosphanum; Cyclophosphoramide; Cyclostin; Cyklofosfamid [Czech]; Cytophosphan; Cytophosphane; Cytoxan; Endoxan; Endoxan R; Endoxan-asta; Endoxana; Endoxanal; Genoxal; Lyophilized cytoxan; N,N-Bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide; N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide; N,N-Bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide; N,N-Bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide; N,N-Bis-(beta-chloraethyl)-N',O-propylen-phosphorsaeure-ester-diamid [German]; N,N-Di(2-chloroethyl)-N,O-propylene-phosphoric acid ester diamide; Neosar; Occupation, cyclophosphamide exposure; Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)-, intramol. Ester; Procytox; SK 20501; Sendoxan; Zyklophosphamid [German]; [ChemIDplus]


Other Organic Compounds


White odorless solid; Liquefies upon loss of crystallization water; Darkens on light exposure; [ICSC] White odorless crystalline solid; [MSDSonline]


Used as defleecing agent for sheep and as an antineoplastic and immunosuppressant drug; [Merck Index] An alkylating agent; [HSDB]


A skin, eye, and respiratory tract irritant; May cause effects on the blood, bladder, CNS, lungs, and heart; Carcinogenic to humans and may cause reproductive toxicity and heritable genetic damage; [ICSC] A severe skin irritant; Common side effects at therapeutic doses include alopecia, sterility, gastrointestinal disturbances, thrombocytopenia, anemia, leukopenia, and life-threatening hemorrhagic cystitis; Rare side effects include hepatitis, interstitial pneumonitis, and pulmonary fibrosis; Teratogenic; [HSDB] May cause serious eye injury; Can be absorbed through skin; [MSDSonline]

Exposure Assessment
Vapor Pressure

4.45E-5 mm Hg

Adverse Effects

Hepatotoxin, Secondary

Reproductive Toxin


IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information


Chemical Information

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Biomedical References

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Related Information in HazMap
Other Information

No other related information on this agent was found.