Agent Name

Cyclopiazonic acid

CAS Number

18172-33-3

Formula

C20-H20-N2-O3

Major Category

Biological Agents

Synonyms

9H-Pyrrolo(1',2':2,3)isoindolo(4,5,6-cd)indol-9-one, 10-acetyl-2,6,6a,7,11a,11b-hexahydro-11-hydroxy-7,7-dimethyl-, (6aalpha,11abeta,11balpha)- (8CI)(9CI); 9H-Pyrrolo(1',2':2,3)isoindolo(4,5,6-cd)indol-9-one, 2,6,6a,7,11a,11b-hexahydro-10-acetyl-7,7-dimethyl-11-hydroxy-, (6a-alpha, 11a-beta, 11b-alpha)-; [ChemIDplus]

Category

Mycotoxins

Description

Solid; [HSDB]

Sources/Uses

Suspected cause of "kodua poisoning" in humans from eating kodo millet seed in India; Mycotoxin produced by Aspergillus and Penicillium; [HSDB] Produced by Penicillium and Aspergillus species in moldy millet or ground nut meal; Also produced by some strains of Penicillium camemberti used to make gourmet cheese; [Reference #1]

Comments

Toxic to muscles, liver, and spleen; In 90-day feeding studies of dogs, caused anorexia, vomiting, diarrhea, dehydration, and CNS depression with focal ulcerations throughout GI tract; All dogs receiving 0.5 to 1.0 mg/kg died before the conclusion of the study; [HSDB] Causes hepatocellular necrosis and acute tubular necrosis at lethal oral doses in rats; [RTECS] Alters ion transport across cell membranes and causes kodua poisoning with symptoms of giddiness and nausea; [Reference #1]

Reference Link

PubMed Full-Text: Mycotoxins

Exposure Assessment
Half Life

24 hours in market-weight pigs; [HSDB]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Other Information

No other related information on this agent was found.