Agent Name

Dimethylaniline

Alternative Name

N,N-Dimethylaniline

CAS Number

121-69-7

Formula

C8-H11-N

Major Category

Nitrogen Compounds

Synonyms

(Dimethylamino)benzene; Aniline, N,N-dimethyl-; Benzenamine, N,N-dimethyl-; Dimethylaniline; Dimethylphenylamine; Dwumetyloanilina [Polish]; N,N-(Dimethylamino)benzene; N,N-Dimethylaniline; N,N-Dimethylbenzenamine; N,N-Dimethylbenzeneamine; N,N-Dimethylphenylamine; NL 63-10P; Versneller NL 63/10; [ChemIDplus] UN2253

Category

Amines, Aromatic

Description

Pale yellow, oily liquid with an amine-like odor; Note: A solid below 36 degrees F; [NIOSH]

Sources/Uses

Used in the synthesis of vanillin, methyl violet, and Michler's ketone; also used as a hardener for plastic resins and a acid scavenger in the manufacture of semisynthetic penicillins and cephalosporins; [ACGIH]

Comments

N,N-diethylaniline and N,N-dimethylaniline are potent methemoglobin-inducers with toxicity similar to aniline. [ILO Encyclo, Aromatic Amino Compounds] Listed in a table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] A skin and eye irritant that can induce methemoglobinemia; Inhalation of high concentrations can cause CNS depression; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

5 ppm

STEL (ACGIH)

10 ppm

PEL (OSHA)

5 ppm

MAK

5 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

N,NDimethylaniline has been reported to be quantitatively less toxic than aniline but produces a very similar effect -- notably, methemoglobinemia [Clayton and Clayton 1981].

Vapor Pressure

0.7 mm Hg

Odor Threshold Low

0.001 ppm

Odor Threshold High

0.2 ppm

Lethal Concentration

LCLo (rat) = 250 mg/m3/4H

Explanatory Notes

Odor threshold from AIHA; Flash point = 63 deg C;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Methemoglobinemia

Methemoglobinemia, Primary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
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