Agent Name

Cycloposine

CAS Number

23185-94-6

Formula

C33-H51-N-O7

Major Category

Biological Agents

Synonyms

3-Glucosyl-11-deoxojervine; beta-D-Glucopyranoside, (3beta,23beta)-17,23-epoxyveratraman-3-yl; 17,23beta-Epoxyveratraman-3beta-yl-beta-D-glucopyranoside; [ChemIDplus]

Category

Plant Toxins

Sources/Uses

A steroid alkaloid of the Veratrum genus; No longer used as an antihypertensive drug; [HSDB]

Comments

Increases the permeability of sodium channels in nerve cells causing continuous stimulation; After ingestion, causes vomiting and abdominal pain followed by hypotension and arrhythmias; Teratogenic in animals; Emergency treatment: "Plants- veratrum alkaloids"; Excessive amounts of veratrum alkaloids can cause death by central respiratory depression; [HSDB] Veratrum alkaloids (e.g., black snakeroot, false hellebore, and skunk cabbage) cause gastroenteritis, bradycardia, paresthesias, and hypotension; [Olson, p. 335-48]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

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Health Studies

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Toxicity Information

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Chemical Information

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Other Information

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