Agent Name

Cyclosporin A

CAS Number

59865-13-3

Formula

C62-H111-N11-O12

Major Category

Biological Agents

Synonyms

(R-(R*,R*-(E)))-Cyclic(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-3-hydroxy-N,4-dimethyl-L-2-amino-6-octenoyl-L-alpha-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl); Antibiotic S 7481F1; Ciclosporin; Ciclosporina [INN-Spanish]; Ciclosporine [INN-French]; Ciclosporine [INN]; Ciclosporinum [INN-Latin]; Cipol N; Consupren; Cyclo(((E)-(2S,3R,4R)-3-hydroxy-4-methyl-2-(methylamino)-6-octenoyl)-L-2-aminobutyryl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl); Cyclo(L-alanyl-D-alanyl-N-methyl-L-leucyl-N-methyl-L-leucyl-N-methyl-L-valyl-((3R,4R,6E)-6,7-didehydro-3-hydroxy-N,4-dimethyl-L-2-aminooctanoyl-L-2-aminobutanoyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methylleucyl); Cyclosporin; Cyclosporine; Cyclosporine A; DRG-0275; Gengraf; Neoplanta; Neoral; OL 27-400; Ramihyphin A; Restasis; S 7481F1; S-Neoral; Sandimmun; Sandimmun Neoral; Sandimmune; Sang 35; Sangcya; [ChemIDplus]

Category

Mycotoxins

Description

White solid; [Merck Index] White powder; [MSDSonline]

Sources/Uses

Produced by Tolypocladium inflatum and other fungi imperfecti; An immunosuppressant; Veterinary applications include control of immune-mediated dermatological diseases; [Merck Index] Used in organ transplantation; [HSDB] Used as an immunosuppressive drug since the 1980s; [IARC]

Comments

A nephrotoxin and hepatotoxin; [CAMEO] Directly toxic to the kidney; [Olson, p. 41] Causes chronic tubulointerstitial nephritis; [Ford, p. 194] In studies of rats, can cause male sterility and fetotoxicity at high doses; Enhances the development of lymphomas in animals and humans; [IARC] When used as a drug, nephrotoxicity occurs in all patients and is the limiting factor in its use. Nephrotoxicity is associated with trough plasma levels >250 ng/mL and hepatotoxicity with trough levels >1000 ng/mL; [HSDB]

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

IARC Carcinogen

Known Carcinogen

NTP Carcinogen

Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Biomedical References

Search PubMed

Related Information in HazMap
Other Information

No other related information on this agent was found.