Agent Name

Naled

Alternative Name

Dibrom

CAS Number

300-76-5

Formula

C4-H7-Br2-Cl2-O4-P

Major Category

Pesticides

Synonyms

1,2-Dibromo-2,2-dichloroethyl dimethyl phosphate; Alvora; Arthodibrom; BRP; Bromchlophos; Bromex; Bromex (insecticide); Bromex 50; Dibrom; Dibromfos; Dimethyl 1,2-dibromo-2,2-dichloroethyl phosphate; Ethanol, 1,2-dibromo-2,2-dichloro-, dimethyl phosphate; Flibol Ex; Fosbrom; Fosforan O-1,2-dwubromo-2,2-dwuchloroetylo-O,O-dwumetylowy [Polish]; Hibrom; Naledu [Polish]; Nikabrom; O,O-Dimethyl O-2,2-dichloro-1,2-dibromoethyl phosphate; O,O-Dimethyl-O-(1,2-dibrom-2,2-dichlor-aethyl)-phosphat [German]; O,O-Dimethyl-O-(1,2-dibromo-2,2-dichloroethyl)phosphate; O-(1,2-Dibrom-2,2-dichlor-aethyl)-O,O-dimethyl-phosphat [German]; O-(1,2-Dibromo-2,2-dicloro-etil)-O,O-dimetil-fosfato [Italian]; O-(1,2-Dibroom-2,2-dichloor-ethyl)-O,O-dimethyl-fosfaat [Dutch]; OMS 75; Ortho 4355; Ortho-dibrom; Orthodibromo; Phosphate de O,O-dimethyle et de O-(1,2-dibromo-2,2-dichlorethyle) [French]; Phosphoric acid, 1,2-dibromo-2,2-dichloroethyl dimethyl ester (8CI)(9CI); RE-4355; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Colorless to white solid or straw-colored liquid (above 80 degrees F) with a slightly pungent odor. [insecticide]; [NIOSH]

Sources/Uses

Used to kill aphids, mites, mosquitoes, and flies; also used by veterinarians to treat worm infections in dogs; [EXTOXNET] Used as an insecticide and acaricide in field crops, greenhouses and mushroom cultivation; Also used to kill mosquitoes; [ACGIH]

Comments

Classified as "moderately toxic," naled has an LD50 of 91 to 430 mg/kg in rats; Skin sensitization has been reported; [EXTOXNET] Structurally similar to dichlorvos; A dermal sensitizer; [ACGIH]

Reference Link

EXTOXNET PIP - NALED

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 mg/m3, inhalable fraction and vapor

PEL (OSHA)

3 mg/m3

MAK

1 mg/m3, inhalable fraction

IDLH (NIOSH)

200 mg/m3

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: Because no useful data on acute inhalation toxicity are available, the chosen IDLH has been estimated from the male rat oral LD50 of 250 mg/kg [Gaines 1969 cited by ACGIH 1971]. ACGIH [1971] also reported that the acute toxicity data, inhalation data, and experience to date indicate that this is not a highly dangerous material. . . . Human data: None relevant for use in determining the revised IDLH.

Vapor Pressure

0.0002 mm Hg

Lethal Concentration

LC (mice) > 1,500 mg/m3/6h

Reference Link

EPA Pesticide Chemical Search

Adverse Effects
Skin Sensitizer

Yes

Other Poison

Organophosphate

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: