Agent Name

Phosfolan

Alternative Name

Cyolane

CAS Number

947-02-4

Formula

C7-H14-N-O3-P-S2

Major Category

Pesticides

Synonyms

Cyolane; (Diethoxyphosphinyl)dithioimidocarbonic acid cyclic ethylene ester; 1,2-Ethanedithiol, cyclic S,S-ester with phosphonodithioimidocarbonic acid P,P-diethyl ester; 1,2-Ethanedithiol, cyclic ester with P,P-diethyl phosphonodithioimidocarbonate; 2-(Diethoxyphosphinylimino)-1,3-dithiolane; AC 47031; American Cyanamid 47031; American Cyanamid AC 47,031; American Cyanamid CL-47031; American Cyanamide 47031; CL 47031; Cyclic ethylene P,P-diethyl phosphonodithioimidocarbonate; Cyclic ethylene(diethoxyphosphinothioyl)dithioimidocarbonate; Cyolane insecticide; Diethyl 1,3-dithiolan-2-ylidenephosphoramidate (9CI); EI 47031; ENT 25,830; Imidocarbonic acid, (diethoxyphosphinyl)dithio-, cyclic ethylene ester; Imidocarbonic acid, phosphonodithio-, P,P-diethyl cyclic ethylene ester; Imidocarbonic acid, phosphonodithio-, cyclic ethylene P,P-diethyl ester; OMS 646; P,P-Diethyl cyclic ethylene ester of phosphonodithioimidocarbonic acid; P,P-Diethyl cyclic ethylene phosphonodithioimidocarbonate (8CI); Phospholan [ISO-French]; Phosphoramidic acid, 1,3-dithiolan-2-ylidene-, diethyl ester; [ChemIDplus]

Category

Organophosphate Insecticides

Description

Colorless to yellow solid; [CAMEO] Yellow crystalline solid; [MSDSonline]

Sources/Uses

Used as systemic insecticide; [HSDB]

Comments

Decreased erythrocyte cholinesterase activity in heavy occupational exposure by 31-43% by the end of the first hour; Nearly half of the cholinesterase activity had recovered by 48 hours, with full recovery taking 3-4 weeks; No adverse clinical observations in 90 day feeding with dogs at 1 mg/kg; Cholinesterase inhibition noted in animal studies, but no chronic neurotoxicity seen in chickens surviving high doses; [HSDB]

Exposure Assessment
BEI

Cholinesterase activity in red cells = 70% of individual's baseline, sample time discretionary; [ACGIH]

Vapor Pressure

5.3E-5 mm Hg

Adverse Effects
Other Poison

Organophosphate

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: