Agent Name

Cytochalasin B

CAS Number

14930-96-2

Formula

C29-H37-N-O5

Major Category

Biological Agents

Synonyms

(E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-16-Benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-2H-oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione; 24-Oxa(14)cytochalasa-6(12),13,21-triene-1,23-dione, 7,20-dihydroxy-16-methyl-10-phenyl-, (7S,13E,16R,20R,21E)-; 2H-Oxacyclotetradec(2,3-d)isoindole-2,18(5H)-dione, 16-benzyl-6,7,8,9,10,12a,13,14,15,15a,16,17-dodecahydro-5,13-dihydroxy-9,15-dimethyl-14-methylene-, (E,E)-(5S,9R,12aS,13S,15S,15aS,16S,18aS)-; Phomin; [ChemIDplus]

Category

Mycotoxins

Description

Solid; [Merck Index] White crystalline solid; [MSDSonline]

Sources/Uses

Cytochalasins are a group of mold metabolites having various effects on animal cells; More than twenty cytochalasins have been isolated from different mold species; Used in cytological research and in studying the polymerization properties of actin; Most studied is cytochalasin B; [Merck Index]

Comments

Causes ataxia, cyanosis, and coma at lethal doses in rats; Intraperitoneal LD50 (rat) = 11 mg/kg; [RTECS] Cause inhibitory effects on cell processes; No reports of chronic effects or carcinogenicity in humans; [HSDB] Target organ is the liver; An irritant; May be fatal if inhaled or ingested; Teratogenic; [Aldrich MSDS]

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