Agent Name

Cytochalasin D

CAS Number

22144-77-0

Formula

C30-H37-N-O6

Major Category

Biological Agents

Synonyms

(11)Cytochalasa-6(12),13,19-triene-1,17-dione, 21-(acetyloxy)-7,18-dihydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E,21R)-; 1H-Cycloundec(d)isoindole-1,11(2H)-dione, 3-benzyl-3,3-alpha4,5,6,6-alpha,9,10,12,15-decahydro-6,12,15-trihydroxy-4,10,12-trimethyl-5-methylene-, 15-acetate; 7,18-Dihydroxy-10-phenyl-5,16,18-trimethyl-(11)cytochalas-21-acetoxy-6(12),13,19-trien-17-one; Lygosporin A; Zygosporin A; [ChemIDplus]

Category

Mycotoxins

Description

Solid; [HSDB] White solid; [CAMEO] White powder; [MSDSonline]

Sources/Uses

Cytochalasins are a group of mold metabolites having various effects on animal cells; More than twenty cytochalasins have been isolated from different mold species; Used in cytological research and in studying the polymerization properties of actin; Most studied is cytochalasin B; [Merck Index]

Comments

Causes spastic paralysis in mice at lethal doses; Intraperitoneal LD50 (mouse) = 2 mg/kg; [RTECS] Causes inhibitory effects on cell processes; 10 times more potent that cytochalasin B in inhibiting movement and cytoplasmic cleavage; No reports of chronic effects or carcinogenicity in humans; [HSDB] See "Cytochalasin B."

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