Agent Name

Bis(2-(dimethylamino)ethyl) ether

CAS Number

3033-62-3

Formula

C8-H20-N2-O

Major Category

Nitrogen Compounds

Synonyms

2,2'-Oxybis(N,N-dimethylethylamine); A 99 (Amine); Bis(2-dimethylaminoethyl) ether; Bis(2-dimethylaminoethyl)ether; Dabco BL 11; Dabco BL 19; Dabco BL 19I; Kalpur PC; Niax A 1; Niax A 4; Niax A 99; Niax catalyst al; Texacat ZF 20; Toyocat ET; Toyocat ETS; [ChemIDplus]

Category

Other Nitrogen Compounds

Description

A clear or yellow liquid; [CAMEO]

Sources/Uses

A component (5%) of NIAX Catalyst ESN, along with dimethylaminopropionitrile (95%); used in the past as a catalyst in the manufacture of flexible polyurethane foams; [NIOSH]

Comments

Toxic to the autonomic nervous system; "In May 1978, OSHA and NIOSH jointly published the Current Intelligence Bulletin (CIB) 26: NIAX Catalyst ESN. In this CIB, OSHA and NIOSH recommended that occupational exposure to NIAX Catalyst ESN, its components, dimethylaminopropionitrile and bis(2-(dimethylamino)ethyl)ether, as well as formulations containing either component, be minimized. Exposures should be limited to as few workers as possible, while minimizing workplace exposure concentrations with effective work practices and engineering controls. Exposed workers should be carefully monitored for potential disorders of the nervous and genitourinary system. Although substitution is a possible control measure, alternatives to NIAX Catalyst ESN or its components should be carefully evaluated with regard to possible adverse health effects." [NIOSH Pocket Guide Appendix]

Restricted

See Appendix C in NIOSH Pocket Guide. The neurotoxicity was apparently due to DMAPN (dimethylaminopropionitrile). See NIOSHTIC Record # 57566. CIB 26 published by NIOSH & OSHA in 1978.

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.05 ppm

STEL (ACGIH)

0.15 ppm

Lethal Concentration

LC50 (rat) = 117 ppm/6h

Links to Other NLM Databases
Health Studies

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