Agent Name

Dinitro-o-cresol

Alternative Name

Dinitro-ortho-cresol

CAS Number

534-52-1

Formula

C7-H6-N2-O5

Major Category

Pesticides

Synonyms

Dinitro-ortho-cresol; 2,4-Dinitro-6-methylphenol; 2,4-Dinitro-o-cresol; 2-Methyl-4,6-dinitrophenol; 3,5-Dinitro-2-hydroxytoluene; 4,6-Dinitro-o-cresol; 4,6-Dinitro-o-cresolo [Italian]; 4,6-Dinitro-o-kresol [Czech]; 4,6-Dinitrokresol [Dutch]; 6-Methyl-2,4-dinitrophenol; AI3-01567; Antinonin; Antinonnin; Arborol; C.I. 10310; Capsine; Chemsect DNOC; DNOC; DNOK [Czech]; Degrassan; Dekrysil; Detal; Dillex; Dinitro; Dinitro-o-cresol (VAN); Dinitrocresol; Dinitrodendtroxal; Dinitrol; Dinoc; Dinurania; Ditrosol; Dn-dry mix no. 2; Dwunitro-o-krezol [Polish]; Effusan; Effusan 3436; Elgetol; Elgetol 30; Elipol; Extrar; Flavin-Samdoz; Hedolit; Hedolite; K III; K IV; Kreozan; Kresamone; Kresonite-E; Krezotol 50; LE dinitrocresol-4,6 [French]; Lipan; Neudorff DN 50; Nitrador; Nitrofan; Oranz viktoria [Czech]; Prokarbol; Rafex; Rafex 35; Raphatox; Sandolin; Sandolin A; Selinon; Sinox; Toluene, 3,5-dinitro-2-hydroxy-; Trifocide; Trifrina; Winterwash; Zahlreiche bezeichnungen [German]; o-Cresol, 4,6,-dinitro-; [ChemIDplus]

Category

Herbicides, Nitroaromatic

Description

Yellow, odorless solid. [insecticide]; [NIOSH]

Sources/Uses

"DNOC is used as a selective herbicide and as an insecticide." [ACGIH]

Comments

The pathophysiology, like that of pentachlorophenol, involves the uncoupling of oxidative phosphorylation. Yellow stains appear on the skin after dermal contact with the nitroaromatic herbicides. Fatal poisoning can occur after dermal absorption. Cataracts have been reported in animal experiments and after occupational exposure. In severe poisoning, these herbicides can cause injury to the liver and kidneys. [EPA Pesticides, p. 104-5] Sheep fed 70 mg/kg develop a moderate methemoglobinemia with dyspnea and hyperthermia. DNOC is absorbed by inhalation and through the skin. Most occupational poisonings occurred in agricultural workers. [ACGIH] Secondary acute renal failure after dinitrophenol and dinitro-o-cresol poisoning has been reported. [LaDou, p. 418] 4,6--Dinitro-o-cresol is a potential skin sensitizer. [Quick CPC]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.2 mg/m3

PEL (OSHA)

0.2 mg/m3

IDLH (NIOSH)

5 mg/m3

Excerpts from Documentation for IDLHs

Human data: An exposure of 4.7 mg/m3 per day resulted in fever, a basal metabolic rate of 400, rapid pulse and respiration, profuse sweating, shortness of breath, and cough [Fairhall 1957]. A single oral dose 75 mg produced no toxic effects in five volunteers [Harvey et al. 1951]. [Note: An oral dose of 75 mg is equivalent to a worker being exposed to 50 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Vapor Pressure

5.0E-5 mm Hg

Lethal Concentration

LCLo (cats) = 40 mg/m3/4 hr

Half Life

No reports found; [TDR, p. 567]

Reference Link

ATSDR - ToxFAQs - Dinitrocresols

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Methemoglobinemia

Methemoglobinemia, Secondary

Other Poison

Uncoupler

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: