Agent Name

Deoxynivalenol

Alternative Name

Vomitoxin

CAS Number

51481-10-8

Formula

C15-H20-O6

Major Category

Biological Agents

Synonyms

Vomitoxin; 12,13-Epoxy-3-alpha,7-alpha,15-trihydroxy-9-trichothecen-8-one; 4-Deoxynivalenol; 4-Desoxynivalenol; DON; Dehydronivalenol; Desoxynivalenol; Rd toxin; [ChemIDplus]

Category

Mycotoxins

Description

Solid; [Merck Index]

Sources/Uses

A trichothecene mycotoxin; [Merck Index] Reportedly used as biological/chemical warfare agent; [HSDB] Zearalenone, deoxynivalenol, and fusarenon X are mycotoxins produced by 3 Fusarium species (F. graminearum, F. culmorum, and F. crookwellense) that grow on wheat, barley, and maize in humid conditions. [IARC] Common contaminant of barley, corn, rye, safflower seeds, wheat, and mixed feeds; [Reference #1]

Comments

In humans, severe gastrointestinal reactions occur after ingestion. In pigs, causes feed refusal and vomiting; Causes immunosuppression in mice studies; No data on carcinogenicity in animals; [IARC] Trichothecene mycotoxins causes bone marrow suppression, leukopenia, immunosuppression, and secondary sepsis; [HSDB] Inhibits eukaryotic protein synthesis; Less potent than T-2 toxin; Has also been called "vomitoxin" and "food-refusal factor." [Reference #1] Fatal if swallowed; Causes mild skin irritation; [Aldrich MSDS] See "T-2 toxin."

Reference Link

PubMed Full-Text: Mycotoxins

Exposure Assessment
Vapor Pressure

6.8E-11 mm Hg

Adverse Effects
IARC Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Other Information

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