Agent Name

Polybrominated biphenyls

CAS Number

59536-65-1

Major Category

Other Classes

Synonyms

Firemaster BP-6; Biphenyl, hexabromo- (technical grade); Hexabromobiphenyl (technical grade); PBB; Polybrominated biphenyls; [ChemIDplus]

Category

Halogenated Polyaromatics

Sources/Uses

Used as flame retardants; [Sullivan, p. 766]

Comments

In animal studies, the effects are similar to those of PCBs. No human diseases have been linked to occupational exposure to polybrominated biphenyls. [Sullivan, p. 766] Listed in a table of "Chloracne-Producing Chemicals"; [Rosenstock, p. 714] There is evidence that PBBs can cause fetal loss and testicular damage in experimental animals. [ATSDR Case Studies #29] "The accepted view is that exposure to PBBs or PCBs leads to hepatic injury only when they are sufficiently contaminated with PCDFs." (PCDFs = polychlorinated dibenzofurans.) [Zimmerman, p. 395] Polybrominated biphenyls cause malignant liver tumors in feeding studies of rats and mice; [IARC] See "2,4,5,2',4',5'-Hexabromobiphenyl."

Restricted

The manufacturing of PBBs stopped in the US in 1976. [ATSDR ToxFAQs]

Exposure Assessment
Bioaccumulates

Yes

Reference Link

ATSDR - ToxFAQs - Polybrominated Biphenyls (PBBs)

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Reproductive Toxin

Yes

Dermatotoxin

Chloracne

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Toxicity Information

Search TOXNET

Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: