Agent Name

o-Dinitrobenzene

CAS Number

528-29-0

Formula

C6-H4-N2-O4

Major Category

Nitrogen Compounds

Synonyms

1,2-Dinitrobenzene; Dinitrobenzene (Ortho) {1,2-Dinitrobenzene}; O-Dinitrobenzol; Ortho-Dinitrobenzene; [CAMEO] UN3443

Category

Nitros, Aromatic

Description

Pale-white or yellow, crystalline solid; [NIOSH]

Sources/Uses

Used in the manufacture of dyes, explosives, and celluloids; [ACGIH]

Comments

Potential to cause methemoglobinemia, liver damage, and visual impairment; Listed in table of "Industrial Chemicals for Which Methemoglobin Formation is the Principal Cause of Toxicity"; [ACGIH] An eye and respiratory tract irritant; Can induce methemoglobinemia and have effects on the liver; [ICSC]

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Yes

TLV (ACGIH)

1 mg/m3

PEL (OSHA)

1 mg/m3

IDLH (NIOSH)

50 mg/m3

Excerpts from Documentation for IDLHs

Human data: The probable lethal oral dose has been reported to be 2 grams [Deichmann and Gerarde 1969]. [Note: An oral dose of 2 grams is equivalent to a worker being exposed to about 1,300 mg/m3 for 30 minutes, assuming a breathing rate of 50 liters per minute and 100% absorption.]

Vapor Pressure

4.55E-5 mm Hg

Explanatory Notes

Flash point = 302 deg F;

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Primary

Links to Other NLM Databases
Health Studies

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: