Agent Name

Diacetoxyscirpenol

CAS Number

2270-40-8

Formula

C19-H26-O7

Major Category

Biological Agents

Synonyms

3-alpha-Hydroxy-4-beta,15-diacetoxy-12,13-epoxytrichothec-9-ene; 4,15-Di-O-acetylscirpenol; 4,15-Diacetoxyscirp-9-en-3-ol; 4,15-Diacetoxyscirpen-3-ol; 4,15-Diacetoxyscirpenol; 4beta,15-Diacetoxy-3alpha-hydroxy-12,13-epoxytrichothec-9-ene; ANG 66; Anguidin; Anguidine; DAS; Diazetoxyskirpenol [German]; MM 4462; Scirp-9-ene-3alpha,4beta,15-triol, 4,15-diacetate; Scirpenetriol 4,15-diacetate; Trichothec-9-ene, 12,13-epoxy-4beta,15-diazetoxy-3alpha-hydroxy-; Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 4,15-diacetate; [ChemIDplus] UN3462

Category

Mycotoxins

Description

Solid; [HSDB]

Sources/Uses

A mycotoxin of the group 12,13-epoxytrichothecene; [ChemIDplus] Reportedly used as biological/chemical warfare agent; [HSDB]

Comments

Trichothecene mycotoxins causes bone marrow suppression, leukopenia, and immunosuppression with susceptibility to sepsis; [HSDB] Of the naturally occurring trichothecenes, T-2 and diacetoxyscirpenol are the most potent; [Reference #1] Irritating to skin and eyes; Very toxic by inhalation, skin contact, or ingestion; Targets thymus, bone marrow, spleen, blood, and nerves; Effects in high-dose animal studies include allergic dermatitis and cyanosis; Causes GI bleeding after ingestion; [Aldrich MSDS] See "Deoxynivalenol." See "T-2 toxin."

Reference Link

PubMed Full-Text: Mycotoxins

Exposure Assessment
Lethal Concentration

LC50 (mice) = 11.3 mg/kg

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Other Information

No other related information on this agent was found.