| Agent Name | Diacetoxyscirpenol |
|---|---|
| CAS Number | 2270-40-8 |
| Formula | C19-H26-O7 |
| Major Category | Biological Agents |
| Synonyms | 3-alpha-Hydroxy-4-beta,15-diacetoxy-12,13-epoxytrichothec-9-ene; 4,15-Di-O-acetylscirpenol; 4,15-Diacetoxyscirp-9-en-3-ol; 4,15-Diacetoxyscirpen-3-ol; 4,15-Diacetoxyscirpenol; 4beta,15-Diacetoxy-3alpha-hydroxy-12,13-epoxytrichothec-9-ene; ANG 66; Anguidin; Anguidine; DAS; Diazetoxyskirpenol [German]; MM 4462; Scirp-9-ene-3alpha,4beta,15-triol, 4,15-diacetate; Scirpenetriol 4,15-diacetate; Trichothec-9-ene, 12,13-epoxy-4beta,15-diazetoxy-3alpha-hydroxy-; Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 4,15-diacetate; [ChemIDplus] UN3462 |
| Category | Mycotoxins |
| Description | Solid; [HSDB] |
| Sources/Uses | A mycotoxin of the group 12,13-epoxytrichothecene; [ChemIDplus] Reportedly used as biological/chemical warfare agent; [HSDB] |
| Comments | Trichothecene mycotoxins causes bone marrow suppression, leukopenia, and immunosuppression with susceptibility to sepsis; [HSDB] Of the naturally occurring trichothecenes, T-2 and diacetoxyscirpenol are the most potent; [Reference #1] Irritating to skin and eyes; Very toxic by inhalation, skin contact, or ingestion; Targets thymus, bone marrow, spleen, blood, and nerves; Effects in high-dose animal studies include allergic dermatitis and cyanosis; Causes GI bleeding after ingestion; [Aldrich MSDS] See "Deoxynivalenol." See "T-2 toxin." |
| Reference Link | |
| Exposure Assessment | |
| Lethal Concentration | LC50 (mice) = 11.3 mg/kg |
| Explanatory Notes | The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s." |
| Adverse Effects | |
| Toxic Pneumonitis | Yes |
| Dermatotoxin | Skin Burns |
| Links to Other NLM Databases | |
| Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
| Toxicity Information | |
| Chemical Information | |
| Related Information in HazMap | |
| Other Information | No other related information on this agent was found. |
Agent Name
Diacetoxyscirpenol
CAS Number
2270-40-8
Formula
C19-H26-O7
Major Category
Biological Agents
Synonyms
3-alpha-Hydroxy-4-beta,15-diacetoxy-12,13-epoxytrichothec-9-ene; 4,15-Di-O-acetylscirpenol; 4,15-Diacetoxyscirp-9-en-3-ol; 4,15-Diacetoxyscirpen-3-ol; 4,15-Diacetoxyscirpenol; 4beta,15-Diacetoxy-3alpha-hydroxy-12,13-epoxytrichothec-9-ene; ANG 66; Anguidin; Anguidine; DAS; Diazetoxyskirpenol [German]; MM 4462; Scirp-9-ene-3alpha,4beta,15-triol, 4,15-diacetate; Scirpenetriol 4,15-diacetate; Trichothec-9-ene, 12,13-epoxy-4beta,15-diazetoxy-3alpha-hydroxy-; Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 4,15-diacetate; [ChemIDplus] UN3462
Category
Mycotoxins
Description
Solid; [HSDB]
Sources/Uses
A mycotoxin of the group 12,13-epoxytrichothecene; [ChemIDplus] Reportedly used as biological/chemical warfare agent; [HSDB]
Comments
Trichothecene mycotoxins causes bone marrow suppression, leukopenia, and immunosuppression with susceptibility to sepsis; [HSDB] Of the naturally occurring trichothecenes, T-2 and diacetoxyscirpenol are the most potent; [Reference #1] Irritating to skin and eyes; Very toxic by inhalation, skin contact, or ingestion; Targets thymus, bone marrow, spleen, blood, and nerves; Effects in high-dose animal studies include allergic dermatitis and cyanosis; Causes GI bleeding after ingestion; [Aldrich MSDS] See "Deoxynivalenol." See "T-2 toxin."
Reference Link
Exposure Assessment
Lethal Concentration
LC50 (mice) = 11.3 mg/kg
Explanatory Notes
The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s."
Adverse Effects
Toxic Pneumonitis
Yes
Dermatotoxin
Skin Burns
Links to Other NLM Databases
Toxicity Information
Chemical Information
Related Information in HazMap
Other Information
No other related information on this agent was found.