Agent Name | Diacetoxyscirpenol |
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CAS Number | 2270-40-8 |
Formula | C19-H26-O7 |
Major Category | Biological Agents |
Synonyms | 3-alpha-Hydroxy-4-beta,15-diacetoxy-12,13-epoxytrichothec-9-ene; 4,15-Di-O-acetylscirpenol; 4,15-Diacetoxyscirp-9-en-3-ol; 4,15-Diacetoxyscirpen-3-ol; 4,15-Diacetoxyscirpenol; 4beta,15-Diacetoxy-3alpha-hydroxy-12,13-epoxytrichothec-9-ene; ANG 66; Anguidin; Anguidine; DAS; Diazetoxyskirpenol [German]; MM 4462; Scirp-9-ene-3alpha,4beta,15-triol, 4,15-diacetate; Scirpenetriol 4,15-diacetate; Trichothec-9-ene, 12,13-epoxy-4beta,15-diazetoxy-3alpha-hydroxy-; Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 4,15-diacetate; [ChemIDplus] UN3462 |
Category | Mycotoxins |
Description | Solid; [HSDB] |
Sources/Uses | A mycotoxin of the group 12,13-epoxytrichothecene; [ChemIDplus] Reportedly used as biological/chemical warfare agent; [HSDB] |
Comments | Trichothecene mycotoxins causes bone marrow suppression, leukopenia, and immunosuppression with susceptibility to sepsis; [HSDB] Of the naturally occurring trichothecenes, T-2 and diacetoxyscirpenol are the most potent; [Reference #1] Irritating to skin and eyes; Very toxic by inhalation, skin contact, or ingestion; Targets thymus, bone marrow, spleen, blood, and nerves; Effects in high-dose animal studies include allergic dermatitis and cyanosis; Causes GI bleeding after ingestion; [Aldrich MSDS] See "Deoxynivalenol." See "T-2 toxin." |
Reference Link | |
Exposure Assessment | |
Lethal Concentration | LC50 (mice) = 11.3 mg/kg |
Explanatory Notes | The Guide in the Emergency Response Guidebook is for "Toxins, extracted from living sources, solid, n.o.s." |
Adverse Effects | |
Toxic Pneumonitis | Yes |
Dermatotoxin | Skin Burns |
Links to Other NLM Databases | |
Health Studies | Human Health Effects from Hazardous Substances Data Bank: |
Toxicity Information | |
Chemical Information | |
Related Information in HazMap | |
Other Information | No other related information on this agent was found. |