Agent Name

Diphenylamine

CAS Number

122-39-4

Formula

C12-H11-N

Major Category

Nitrogen Compounds

Synonyms

Aniline, N-phenyl-; Anilinobenzene; Benzenamine, N-phenyl-; Benzene, (phenylamino)-; Benzene, anilino-; Big Dipper; C.I. 10355; CI 10355; DFA; DPA (VAN); Deccoscald 282; Difenylamin [Czech]; Diphenylamine; N,N-Diphenylamine; N-Fenylanilin [Czech]; N-Phenylaniline; N-Phenylbenzenamine; Naugalube 428L; No-Scald; No-Scald DPA 283; Phenylaniline; Scaldip; Shield DPA; [ChemIDplus] UN3077

Category

Amines, Polyaromatic

Description

Colorless, tan, amber, or brown crystalline solid with a pleasant, floral odor. (fungicide); [NIOSH]

Sources/Uses

Used as an antioxidant, stabilizer of explosives, fungicide, and analytical chemical reagent; also used in the manufacture of dyes and pesticides; [ACGIH] Used to make dyes, to stabilize nitrocellulose explosives and celluloid, to treat screwworm topically (veterinary), and to test for nitrate or nitrite poisoning; [Merck Index]

Comments

The toxicity of diphenylamine is similar to that of aniline. Hepatotoxic effects have been demonstrated in animals. It can cause bladder irritation and induce methemoglobinemia in workers. As a skin sensitizer it cross-reacts with p-phenylene diamine. [ACGIH] May have effects on the kidneys and blood; A skin, eye, and respiratory tract irritant; [ICSC]

Reference Link

EPA Pesticide Chemical Search

Exposure Assessment
BEI

Methemoglobin in blood = 1.5% of hemoglobin during or at end of shift. [ACGIH]

Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 mg/m3

MAK

5 mg/m3, inhalable fraction

Vapor Pressure

0.00067 mm Hg

Odor Threshold Low

0.02 mg/m3

Explanatory Notes

Odor threshold from AIHA; Flash point = 307 deg F;

Reference Link

ICSC: Diphenylamine

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

Methemoglobinemia

Methemoglobinemia, Primary

ACGIH Carcinogen

Not Classifiable

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Health Studies

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Toxicity Information

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Chemical Information

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Diseases

Occupational diseases associated with exposure to this agent: