Agent Name

Disulfiram

CAS Number

97-77-8

Formula

C10-H20-N2-S4

Major Category

Pesticides

Synonyms

1,1'-Dithiobis(N,N-diethylthioformamide); Abstensil; Abstensyl (Argentina); Abstinil; Abstinyl; Accel TET; Accel TET-R; Alcophobin; Alk-aubs; Antabus; Antabuse; Antadix; Antaenyl; Antaethyl; Antaetil; Antalcol; Antetan; Antetil; Anteyl; Anti-ethyl; Antiaethan; Anticol; Antietanol; Antietil; Antikol; Antivitium; Antivitium (Spain); Aversan; Averzan; Bis((diethylamino)thioxomethyl) disulfide; Bis((diethylamino)thioxomethyl)disulphide; Bis(N,N-diethylthiocarbamoyl) disulfide; Bis(N,N-diethylthiocarbamoyl)disulphide; Bis(diethylthiocarbamoyl) disulfide; Bis(diethylthiocarbamoyl)disulphide; Bonibal; Contralin; Contrapot; Cronetal; Dicupral; Disetil; Disulfan; Disulfiram; Disulfirame [DCIT]; Disulfiramo [INN-Spanish]; Disulfiramum [INN-Latin]; Dupon 4472; Dupont fungicide 4472; Ekagom DTET; Ekagom TEDS; Ekagom TETDS; Ephorran; Esperal [France]; Etabus; Ethyl TUEX; Ethyl thiram; Ethyl thiurad; Ethyl tuads; Ethyldithiourame; Ethyldithiurame; Exhorran; Formamide, 1,1'-dithiobis(N,N-diethylthio-; HOCA; HocakrotenalKrotenal; N,N,N',N'-Tetraethylthiuram disulfide; N,N,N',N'-Tetraethylthiuram disulphide; Nocbin; Nocceler TET; Nocceler TET-G; Noxal; Noxal (VAN); Refusal; Refusal [Netherlands]; Ro-Sulfiram; Ro-Sulfram-500 (USA); Sanceler TET; Sanceler TET-G; Soxinol TET; Stopetyl; TATD; TETD; TTD; TTS; Tenurid; Tenutex; Tetidis; Tetradine; Tetraethylthioperoxydicarbonic diamide; Tetraethylthiram disulfide; Tetraethylthiram disulphide; Tetraethylthiuram disulfide; Tetraethylthiuram disulphide; Tetraethylthiuran disulfide; Tetraethylthiurium disulfide; Tetraetil; Teturam; Teturamin; Thioperoxydicarbonic diamide ((H2N)C(S))2S2, tetraethyl-; Thiosan; Thioscabin; Thiuram E; Thiuram disulfide, tetraethyl-; Thiuranide; Tiuram; Tuads, ethyl; [ChemIDplus]

Category

Dithiocarbamates (Pesticide)

Description

White, yellowish, or light-gray powder with a slight odor.(fungicide); [NIOSH]

Sources/Uses

Used as a fungicide, a rubber accelerator, and a drug to treat alcoholism; [ACGIH]

Comments

Disulfiram is tested in the standard allergen tray as one of the components of the thiuram mix (tetraethylthiuram disulfide); Thiuram-sensitive patients who take Antabuse may develop a generalized contact dermatitis or localized hand and foot dermatitis. [Marks, p. 132] A nurse dispensing disulfiram developed contact dermatitis; [Kanerva, p. 1837] Drug-induced hepatitis has been rarely reported in patients taking therapeutic doses of Antabuse. [HSDB] Poisoning by ingestion (with alcohol): headache, flushing, hypotension, sweating, dizziness, nausea, vomiting, and diarrhea; Poisoning by ingestion (acute overdose): delirium, agitation, CNS depression; Poisoning by ingestion (chronic overdose): encephalopathy and neuropathy; [Ford, p. 591-4]

Reference Link

Occupational allergic contact reaction to disulfir... [Contact Dermatitis. 1994] - PubMed result

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

2 mg/m3

MAK

2 mg/m3, inhalable fraction

Vapor Pressure

0.00087 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

IARC Carcinogen

Not Classifiable

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: