Agent Name

1,4-Benzenedicarbonyl dichloride

Alternative Name

Terephthaloyl chloride

CAS Number

100-20-9

Formula

C8-H4-Cl2-O2

Major Category

Toxic Gases & Vapors

Synonyms

Terephthaloyl chloride; 1,4-Benzenedicarbonyl chloride; Terephthalic acid chloride; Terephthalic acid dichloride; Terephthalic dichloride; Terephthaloyl dichloride; p-Phenylenedicarbonyl dichloride; p-Phthaloyl chloride; p-Phthaloyl dichloride; [ChemIDplus] UN2928

Category

Acid Halides

Description

Colorless or white solid with pungent odor; [ICSC] White flakes; [MSDSonline]

Sources/Uses

Used in dyes, synthetic fibers, resins, films, pharmaceuticals, rubber chemicals, and as a cross-linking agent for polyurethanes and polysulfides; [HSDB]

Comments

A reproductive effector; Causes asphyxiation by upper airway obstruction after lethal-dose inhalation studies of mice; [RTECS] Dust/air mixture may be explosive; Reacts with water producing hydrogen chloride; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause upper airway edema and pulmonary edema; [ICSC] A skin irritant; [HSDB] Reacts with water; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; A lachrymator; Inhalation may cause chemical pneumonitis; Effects in high-dose animal studies include lacrimation, changes in renal tubules and other changes to the brain; [MSDSonline]

Exposure Assessment
Lethal Concentration

LC50 (rat) = 700 mg/m3/4h

Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Toxic solid, corrosive, organic, n.o.s."

Adverse Effects
Lacrimator

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Processes

Industrial Processes with risk of exposure: