Agent Name

Di-n-butyltin dichloride

CAS Number

683-18-1

Formula

C8-H18-Cl2-Sn

Major Category

Metals

Synonyms

Chlorid di-n-butylcinicity [Czech]; Di-n-butyl-zinn-dichlorid [German]; Dibutyldichlorostannane; Dibutyldichlorotin; Dibutylstannium dichloride; Dibutyltin chloride; Dibutyltin dichloride; Dichlorodibutylstannane; Dichlorodibutyltin; Stannane, dibutyldichloro-; Tin, dibutyl-, dichloride; [ChemIDplus] UN3146

Category

Tin Compounds, Organic

Description

White solid; mp = 43 deg C; [Hawley] White paste with an acrid odor; mp = 39-41 deg C; [MSDSonline]

Sources/Uses

Used as organotin intermediate, a general-purpose stabilizers for polyvinyl chloride, an esterification catalyst, and a veterinary vermicide and tapeworm remedy; [HSDB]

Comments

In lethal dose studies by intravenous route, causes somnolence (general depressed activity), chronic pulmonary edema, and liver injury; Oral LD50 (rat) = 50 mg/kg; Intravenous LDLo (rat) = 10 mg/kg; [ChemIDplus] A strong skin and eye irritant; A potent immunotoxin--causes thymus lymphocyte depletion in animal experiments; [HSDB] A delayed skin, eye, and respiratory tract irritant; [INCHEM] Can cause burns; [eChemPortal: ESIS] May evolve hydrochloric acid on exposure to moisture; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Can be absorbed through skin; [MSDSonline] See "Tin, organic compounds."

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

0.1 mg/m3, as Sn

STEL (ACGIH)

0.2 mg/m3, as Sn

PEL (OSHA)

0.1 mg/m3, as Sn

MAK

0.1 mg/m3, inhalable fraction, as Sn

IDLH (NIOSH)

25 mg/m3, as Sn

Lethal Concentration

LC50 (rat) >364 mg/m3/4h

Explanatory Notes

VP = 2 mm Hg at 100 deg C; [HSDB] The Guide in the Emergency Response Guidebook is for "Organotin compound, solid, n.o.s." Organic tin compounds have a "skin" designation and are classified as "A4" (Not classifiable as human carcinogen); [ACGIH]

Adverse Effects
Neurotoxin

Other CNS Neurotoxin

Hepatotoxin

Hepatotoxin, Secondary

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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