Agent Name

Ethylenediamine

Alternative Name

1,2-Diaminoethane

CAS Number

107-15-3

Formula

C2-H8-N2

Major Category

Nitrogen Compounds

Synonyms

1,2-Diamino-ethaan [Dutch]; 1,2-Diamino-ethano [Italian]; 1,2-Diaminoaethan [German]; 1,2-Diaminoethane; 1,2-Ethanediamine; 1,2-Ethylenediamine; Aethaldiamin [German]; Aethylenediamin [German]; Algicode 106L; Amerstat 274; Dimethylenediamine; Ethyleendiamine [Dutch]; Ethylendiamine; Ethylene-diamine [French]; Ethylenediamine; beta-Aminoethylamine; [ChemIDplus] UN1604

Category

Amines, Aliphatic

Description

Colorless, viscous liquid with an ammonia-like odor; [NIOSH]

Sources/Uses

Used in the manufacture of chelating agents, fungicides, waxes, polyamide resins, and corrosion inhibitors. [ACGIH] Used as an emulsifier, an inhibitor in antifreeze solutions, and an additive to pharmaceuticals and textile lubricants; [Merck Index] Used in photography (color developing baths); [www.ci.tucson.az.us/arthazards/medium.html]

Comments

Liquid causes second degree burns after contact for a few minutes; [CHRIS] Corrosive to skin; [Quick CPC] Ethylenediamine is used in topical creams and suppositories, e.g., nystatin cream and aminophylline suppositories. Allergic contact dermatitis has been reported in a pharmacist and in healthcare workers. [Marks, p. 85-7] Allergic contact dermatitis in healthcare workers reported after exposure to intravenous aminophylline preparations containing ethylenediamine; [Kanerva, p. 1520] Occupational asthma reported in shellac handler and photographer; [Malo] Can cause pulmonary edema after an acute inhalation exposure; [ICSC] Danger of skin and airway sensitization; [MAK] Humans complain of nasal irritation after inhaling concentrations of 200 ppm for 5-10 minutes. [CAMEO] A lachrymator; [CHEMINFO]

Reference Link

Occupational asthma due to ethylene diamine

Exposure Assessment
Skin Designation (ACGIH)

Yes

TLV (ACGIH)

10 ppm

PEL (OSHA)

10 ppm

IDLH (NIOSH)

1000 ppm

Excerpts from Documentation for IDLHs

Other animal data: It has been reported that rats have survived an 8hour exposure to 2,000 ppm [Smyth et al. 1951]. Human data: It has been reported that workers will not stay in concentrations of 2,000 ppm [UCC 1971].

Vapor Pressure

12 mm Hg

Odor Threshold Low

1 ppm

Odor Threshold High

11 ppm

Lethal Concentration

LCLo (rat) = 4,000 ppm/8 hr

Explanatory Notes

Odor threshold from CHEMINFO; Flash point = 93 deg F;

Reference Link

ICSC: Ethylenediamine

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Skin Sensitizer

Yes

Lacrimator

Yes

Asthma

Yes

Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: