Agent Name

Ethyl amyl ketone

Alternative Name

5-Methyl-3-heptanone

CAS Number

541-85-5

Formula

C8-H16-O

Major Category

Solvents

Synonyms

5-Methyl-3-heptanone; 2-Methylbutyl ethyl ketone; 3-Methyl-5-heptanone; 5-Methyl-3-heptanone; Ethyl 2-methylbutyl ketone; Ethyl sec-amyl ketone; 3-eptanone, 5-methyl-; [ChemIDplus] EAK; [ACGIH]

Category

Ketones (<C12)

Description

Colorless liquid with a pungent odor; [NIOSH]

Sources/Uses

Used as a solvent for resins; [ACGIH]

Comments

Narcosis induced in animal inhalation studies. Animals fed 820 mg/kg/day develop evidence of peripheral neuropathy. [ACGIH] A skin, eye, and respiratory tract irritant; Inhalation of high concentrations can cause CNS depression; [ICSC]

Exposure Assessment
Skin Designation (ACGIH)

Insufficient data

TLV (ACGIH)

10 ppm

PEL (OSHA)

25 ppm

MAK

10 ppm

IDLH (NIOSH)

100 ppm

Excerpts from Documentation for IDLHs

Basis for original (SCP) IDLH: The chosen IDLH is based on the statement by Patty [1963] that 0 of 6 rats died, but 3 of 6 mice died when exposed for 4 hours to about 3,000 ppm [Shell 1958]. . . . Human data: Humans exposed to 25 ppm experienced irritation of the eyes and respiratory tract and detected a strong odor, while 100 ppm caused irritation of the mucous membranes, headache, and nausea which was too severe to tolerate for more than a few minutes [Clayton and Clayton 1981].

Vapor Pressure

5.03 mm Hg

Odor Threshold Low

5.9 ppm

RD50

760 ppm

Lethal Concentration

LCLo (rat) =3,484 ppm/8H

Explanatory Notes

Odor threshold from AIHA;

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Links to Other NLM Databases
Toxicity Information

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Chemical Information

Search ChemIDplus

Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: