Agent Name

Diethyl sulfate

CAS Number

64-67-5

Formula

C4-H10-O4-S

Major Category

Toxic Gases & Vapors

Synonyms

DES (VAN); Diaethylsulfat [German]; Diethyl sulphate; Diethyl tetraoxosulfate; Diethylester kyseliny sirove [Czech]; Ethyl sulfate; Sulfuric acid, diethyl ester; [ChemIDplus] UN1594

Category

Other Toxic Gases & Vapors

Description

Colorless liquid with an odor of peppermint; darkens with age; [Merck Index] Colorless oily liquid; [MSDSonline]

Sources/Uses

Used mainly to make dyes; Also used as an ethylating agent (pigment production), a finishing agent (textile manufacturing), a dye-set agent (carbonless paper), and an accelerator (sulfation of ethylene); Also used in agricultural chemicals, household products, pharmaceuticals, and cosmetics; [HSDB]

Comments

A skin, eye, and respiratory tract irritant; May cause pulmonary edema; [ICSC] May cause severe burns to eyes and skin; [HSDB] May be fatal by ingestion, inhalation, and skin absorption; [CAMEO] "Germ cell mutagens that have shown to increase the mutant frequency in the progeny of exposed mammals." [MAK] Decomposes in water and releases sulfuric acid; A corrosive substance that can cause injury to the skin, eyes, and respiratory tract; Inhalation may cause chemical pneumonitis; May be absorbed through skin; [MSDSonline]

Exposure Assessment
Vapor Pressure

0.21 mm Hg

Lethal Concentration

LCLo (rat) = 250 ppm/4h

Explanatory Notes

Flash point = 104 deg C; [ICSC]

Flammability (NFPA)

1: Must be preheated

Adverse Effects
Toxic Pneumonitis

Yes

Dermatotoxin

Skin Burns

IARC Carcinogen

Probable Carcinogen

NTP Carcinogen

Anticipated Human Carcinogen

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Processes

Industrial Processes with risk of exposure: