Agent Name

1,2-Benzenediamine dihydrochloride

CAS Number

615-28-1

Formula

C6-H8-N2.2Cl-H

Major Category

Nitrogen Compounds

Synonyms

o-Phenylenediamine dihydrochloride; 1,2-Phenylenediamine dihydrochloride; [ChemIDplus] UN1673

Category

Amines, Aromatic

Description

Brownish-yellow solid; [CAMEO]

Sources/Uses

Used to make dyes; [CAMEO] Not commercially produced in the US; [HSDB]

Comments

Has the potential to form methemoglobin; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] An eye irritant; May cause skin sensitization; [eChemPortal: ESIS]; Harmful by ingestion, inhalation, or skin absorption; May cause allergic skin reaction; Suspected cause of cancer and genetic defects; [Aldrich MSDS] See "p-Phenylenediamine."

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Phenylenediamines."

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent: