Agent Name

1,4-Diaminobenzene dihydrochloride

CAS Number

624-18-0

Formula

C6-H8-N2.2Cl-H

Major Category

Nitrogen Compounds

Synonyms

p-Phenylenediamine HCl; 1,4-Benzenediamine dihydrochloride; 1,4-Phenylenediamine 2-hydrochloride; 1,4-Phenylenediamine dihydrochloride; 4-Aminoaniline dihydrochloride; C.I. 76061; C.I. Oxidation Base 10A; CI 76061; CI Oxidation Base 10A; Durafur Black RC; Fourrine 64; Fourrine DS; Oxidation Base 10A; Pelagol CD; Pelagol Grey CD; Phenylenediamine dihydrochloride; p-Aminoaniline dihydrochloride; p-Benzenediamine dihydrochloride; p-Diaminobenzene dihydrochloride; p-PD HCl; p-PDA HCl; p-Phenylenediamine dihydrochloride; p-Phenylenediamine hydrochloride; para-Phenylenediamine hydrochloride; [ChemIDplus] UN1673

Category

Amines, Aromatic

Description

White to slightly reddish solid; [ICSC] Off-white crystalline powder; [MSDSonline]

Sources/Uses

Used as an analytical reagent (milk, blood, hydrogen sulfide, and amyl alcohol), antioxidant, and in photographic developers; Used formerly in hair and eyelash dyes; [HSDB]

Comments

An eye irritant; Can be absorbed through skin; Can induce methemoglobinemia; May cause skin sensitization and asthma after prolonged contact; May cause kidney injury; [ICSC] The parent compound has caused allergic dermatitis and eye injury in humans; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] A skin, eye, mucous membrane, and upper respiratory tract irritant; May cause asthma, skin sensitization, liver atrophy, and permanent eye injury; [CAMEO] An eye irritant; May cause skin sensitization; [eChemPortal: ESIS] A mutagen; [RTECS] See "p-Phenylenediamine."

Exposure Assessment
Explanatory Notes

The Guide in the Emergency Response Guidebook is for "Phenylenediamines."

Adverse Effects
Skin Sensitizer

Yes

Asthma

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: