Agent Name

Ethylene chlorohydrin

Alternative Name

2-Chloroethanol

CAS Number

107-07-3

Formula

C2-H5-Cl-O

Major Category

Toxic Gases & Vapors

Synonyms

2-Chloorethanol [Dutch]; 2-Chloraethanol [German]; 2-Chlorethanol [German]; 2-Chloro-1-ethanol; 2-Chloro-1-hydroxyethane; 2-Chloroethanol; 2-Chloroethyl alcohol; 2-Cloroetanolo [Italian]; 2-Hydroxyethyl chloride; 2-Monochloroethanol; Aethylenechlorhydrin [German]; Chloroethylowy alkohol [Polish]; Ethanol, 2-chloro-; Ethene, chlorohydrin; Ethylchlorohydrin; Ethyleen-chloorhydrine [Dutch]; Ethylene chlorhydrin; Ethylene chlorohydrin; Ethylene glycol, chlorohydrin; Glicol monocloridrina [Italian]; Glycol chlorohydrin; Glycol monochlorohydrin; Glycolmonochloorhydrine [Dutch]; Glycomonochlorhydrin; Monochlorhydrine du glycol [French]; beta-Chloroethyl alcohol; beta-Hydroxyethyl chloride; delta-Chloroethanol; delta-Chloroethanolchloroethylowy alkohol [Polish]; [ChemIDplus] UN1135

Category

Other Toxic Gases & Vapors

Description

Colorless liquid with a faint, ether-like odor; [NIOSH]

Sources/Uses

Used as a solvent and chemical intermediate; it is formed during the sterilization of supplies with ethylene oxide; [ACGIH] Used as a solvent for cellulose ethers, machine cleaning, and spot removing; [HSDB]

Comments

In acute animal experiments, ethylene chlorohydrin is a potent central nervous system depressant. Autopsy of a worker who died from ethylene chlorohydrin poisoning showed severe damage to the brain, liver, and other organs. [ACGIH] Absorbed through the skin and severely irritating to the eyes and respiratory tract; Causes heart, liver, and kidney damage and respiratory failure; [ICSC] Ethylene chlorohydrin is more toxic to the kidneys than other halogenated hydrocarbons. It readily penetrates through rubber gloves and the skin. [LaDou, p. 417]

Restricted

No currently registered in the U.S. for use as a pesticide; [HSDB]

Exposure Assessment
Skin Designation (ACGIH)

Yes

TIH

Yes

Ceiling (ACGIH)

1 ppm

PEL (OSHA)

5 ppm

MAK

1 ppm

IDLH (NIOSH)

7 ppm

Excerpts from Documentation for IDLHs

Other animal data: Rats exposed for 15 minutes a day at concentrations of 900 to 1,000 ppm died within a few days [Goldblatt and Chiesman 1944]. Repeated 1hour exposures (not defined) to 2 ppm can be fatal to rats [Ambrose 1950]. Human data: Death has resulted from a 2hour exposure at an estimated concentration of 300 ppm [Dierker and Brown 1944].

Vapor Pressure

7.18 mm Hg

Odor Threshold Low

0.4 ppm

Lethal Concentration

LC50 (rat) = 290mg/m3

Explanatory Notes

Odor threshold from CHEMINFO; Flash point = 40 deg C;

Flammability (NFPA)

2: High ambient temperature required

Adverse Effects
Neurotoxin

CNS Solvent Syndrome

Hepatotoxin

Hepatotoxin, Secondary

Nephrotoxin

Yes

ACGIH Carcinogen

Not Classifiable

Links to Other NLM Databases
Health Studies

Human Health Effects from Hazardous Substances Data Bank:

Toxicity Information

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Chemical Information

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Biomedical References

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

Industrial Processes with risk of exposure: