Agent Name

2-Methyl-1,4-benzenediamine dihydrochloride

CAS Number

615-45-2

Formula

C7-H10-N2.2Cl-H

Major Category

Nitrogen Compounds

Synonyms

1,4-Benzenediamine, 2-methyl-, dihydrochloride; 2,5-Diaminotoluene dihydrochloride; Toluene-2,5-diamine, dihydrochloride; p-Toluenediamine dihydrochloride; [ChemIDplus]

Category

Amines, Aromatic

Description

Solid; [MSDSonline]

Sources/Uses

Used in hair dyes; [HSDB]

Comments

Teratogenic in mice dosed by SC or IP injection on day eight of pregnancy; Emergency treatment: "Paraphenylenediamine"; In sensitized individuals, paraphenylenediamine may cause allergic contact dermatitis following application as a hair dye and asthma following inhalation; Following ingestion, can cause angioneurotic edema, methemoglobinemia, acute tubular necrosis, and hepatotoxicity; An adult died after ingestion of 3 grams of p-phenylenediamine; Another adult who ingested 1800 mg developed angioneurotic edema and acute renal failure; [HSDB] An irritant; May cause skin sensitization; [MSDSonline] See "2,5-Diaminotoluene." See "p-Phenylenediamine."

Exposure Assessment
Vapor Pressure

4.12E-12 mm Hg

Adverse Effects
Skin Sensitizer

Yes

Hepatotoxin

Hepatotoxin, Secondary

Methemoglobinemia

Methemoglobinemia, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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Chemical Information

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Related Information in HazMap
Diseases

Occupational diseases associated with exposure to this agent:

Processes

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