Agent Name

Diisononyl phthalate

Alternative Name

DINP

CAS Number

28553-12-0

Formula

C26-H42-O4

Major Category

Plastics & Rubber

Synonyms

DINP; 1,2-Benzenedicarboxylic acid, diisononyl ester; Baylectrol 4200; DINP; DINP2; DINP3; Diisononylphthalate; ENJ 2065; Isononyl alcohol, phthalate (2:1); JAY-DINP; Jayflex DINP; Palatinol DN; Palatinol N; Phthalic acid, diisononyl ester; Phthalisocizer DINP; Sansocizer DINP; Vestinol 9; Vestinol NN; Vinylcizer 90; Witamol 150; [ChemIDplus]

Category

Phthalate Esters

Description

Viscous oily liquid; [ICSC]

Sources/Uses

Used as a plasticizer for PVC and flexible vinyls; [Merck Index]

Comments

"Tumors have been detected in experimental animals but may not be relevant to humans." [ICSC] "DINP is not a pure substance, but a complex mixture containing mainly C9-branched isomers, with mean formula C26H42O4." No evidence of irritation or other adverse effects in animals exposed to saturated vapor (0.067 mg/L); No pathohistological changes noted in 344 rats fed 2000 mg/kg/day for 7 days; Depression, labored breathing, and weight loss were observed in 30 rats fed 10,000 mg/kg; All rats recovered, and there were no major necropsy findings. Rats fed 500 mg/kg/day for 3 months have liver changes; In a study of rats fed up to 1000 mg/kg/day, the conclusion was that NINP "is not teratogenic or a selective developmental toxicant." Oral LD50 (rat) >10 g/kg; Like dioctyl phthalate, it may cause CNS depression and mild liver toxicity after ingestion of large amounts; [HSDB] A very mild skin and eye irritant, based on animal studies; [CHEMINFO] May cause irritation; [MSDSonline] See "PHTHALATE ESTERS."

Exposure Assessment
Vapor Pressure

5.4E-7 mm Hg

Lethal Concentration

LC50 (rat) > 4,400 mg/m3/4h

Adverse Effects
Hepatotoxin

Hepatotoxin, Secondary

Links to Other NLM Databases
Health Studies

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Toxicity Information

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